Evidence map›Paper›PMID 21034970›Full record

ReviewAdvances in immunology2010

Innate signaling networks in mucosal IgA class switching.

Alejo Chorny, Irene Puga, Andrea Cerutti

Abstract readReview
In one paragraph

Review in Advances in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Comparative Immunomodulatory Profiles ofJournal of microbiology and biotechnology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Vaccine therapy for dysbiosis-related diseases.World journal of gastroenterology · 2020
    Review
  15. Article
  16. Article
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alejo ChornyDepartment of Medicine, The Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA.
Irene Puga
Andrea Cerutti

Funding

Regulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3M
Regulation of antibody diversification and production in HIV-1 infectionR01AI074378 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2008 to 2012
$2.1M
NIAID NIH HHS R01 AI-05753NIAID NIH HHS R01 AI057653NIAID NIH HHS R01 AI-074378NIAID NIH HHS R01 AI074378
6 · The paper itself

Abstract

The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the differentiation of T cells. Additional studies have elucidated the pathways followed by T cells to initiate immunoglobulin responses in B cells. In this review, we discuss recent advances on the mechanisms by which intestinal bacteria, epithelial cells, dendritic cells, and macrophages cross talk with intestinal T cells and B cells to induce frontline immunoglobulin A class switching and production.

Indexed as

AnimalsHumansImmunity, InnateImmunity, MucosalImmunoglobulin A, SecretoryImmunoglobulin Class SwitchingIntestinal MucosaSignal TransductionImmunoglobulin A, Secretory

Identifiers

PMID21034970
PMCPMC3046556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.