ArticleItalian journal of pediatrics2010
Basal and adrenocorticotropic hormone stimulated plasma cortisol levels among Egyptian autistic children: relation to disease severity.
Article in Italian journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Alteration of peripheral cortisol and autism spectrum disorder: A meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Hyperandrogenism? Increased 17, 20-Lyase Activity? A Metanalysis and Systematic Review of Altered Androgens in Boys and Girls with Autism.International journal of molecular sciences · 2021Pooled it
- Concurrent Assessment of Neurotrophic Factors and HPA-Axis Hormones in Early Childhood Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Alterations of several types of metabolites related to microbiota-gut-brain axis in urine of children with autism spectrum disorder.Frontiers in psychiatry · 2026Article
- Vasopressin as Possible Treatment Option in Autism Spectrum Disorder.Biomedicines · 2023Review
- Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Stress System Activation in Children and Adolescents With Autism Spectrum Disorder.Frontiers in neuroscience · 2021Review
- Are Steroid Hormones Dysregulated in Autistic Girls?Diseases (Basel, Switzerland) · 2020Article
- Steroid Metabolites Support Evidence of Autism as a Spectrum.Behavioral sciences (Basel, Switzerland) · 2019Article
- Psychophysiological and Behavioral Responses to a Novel Intruder Threat Task for Children on the Autism Spectrum.Journal of autism and developmental disorders · 2017Article
- Severity of Autism Spectrum Disorders: Current Conceptualization, and Transition to DSM-5.Journal of autism and developmental disorders · 2016Article
- Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain.Frontiers in neuroscience · 2016Article
- A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders.Psychoneuroendocrinology · 2014Review
- Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala.Current neuropharmacology · 2014Article
- Abnormal circadian rhythm and cortisol excretion in autistic children: a clinical study.Croatian medical journal · 2013Article
- Investigation of the serum levels of anterior pituitary hormones in male children with autism.Molecular autism · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism is a disorder of early childhood characterized by social impairment, communication abnormalities and stereotyped behaviors. The hypothalamic-pituitary-adrenocortical (HPA) axis deserves special attention, since it is the basis for emotions and social interactions that are affected in autism.
aimTo assess basal and stimulated plasma cortisol, and adrenocorticotropic hormone (ACTH) levels in autistic children and their relationship to disease characteristics.
methodsFifty autistic children were studied in comparison to 50 healthy age-, sex- and pubertal stage- matched children. All subjects were subjected to clinical evaluation and measurement of plasma cortisol (basal and stimulated) and ACTH. In addition, electroencephalography (EEG) and intelligence quotient (IQ) assessment were done for all autistic children.
resultsSixteen% of autistic patients had high ACTH, 10% had low basal cortisol and 10% did not show adequate cortisol response to ACTH stimulation. Autistic patients had lower basal (p = 0.032) and stimulated cortisol (p = 0.04) and higher ACTH (p = 0.01) than controls. Childhood Autism Rating Scale (CARS) score correlated positively with ACTH (r = 0.71, p = 0.02) and negatively with each of basal (r = -0.64, p = 0.04) and stimulated cortisol (r = -0.88, p < 0.001). Hormonal profile did not differ in relation to EEG abnormalities, IQ and self- aggressive symptoms.
conclusionsThe observed hormonal changes may be due to a dysfunction in the HPA axis in autistic individuals. Further studies are warranted regarding the role of HPA axis dysfunction in the pathogenesis of autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.