ArticleRespiratory research2010
Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Impact of resuscitation with 100% oxygen during physiological-based cord clamping or immediate cord clamping on lung inflammation and injury.Pediatric research · 2026Article
- Preterm lung and brain responses to mechanical ventilation and corticosteroids.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response.Frontiers in immunology · 2023Article
- Tools for assessing lung fluid in neonates with respiratory distress.BMC pediatrics · 2022Article
- Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury.Journal of neuroinflammation · 2021Article
- Surfactant plus budesonide decreases lung and systemic inflammation in mechanically ventilated preterm sheep.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Unraveling the Links Between the Initiation of Ventilation and Brain Injury in Preterm Infants.Frontiers in pediatrics · 2015Review
- Animal Models, Learning Lessons to Prevent and Treat Neonatal Chronic Lung Disease.Frontiers in medicine · 2015Review
- Pressure- versus volume-limited sustained inflations at resuscitation of premature newborn lambs.BMC pediatrics · 2014Article
- Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers.BMC pulmonary medicine · 2014Article
- Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs.PloS one · 2014Article
- Protective ventilation of preterm lambs exposed to acute chorioamnionitis does not reduce ventilation-induced lung or brain injury.PloS one · 2014Article
- Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs.PloS one · 2014Article
- Sustained inflation at birth did not protect preterm fetal sheep from lung injury.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- In-vitro validation of cytokine neutralizing antibodies by testing with ovine mononuclear splenocytes.Journal of comparative pathology · 2013Article
- Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep.Pediatric research · 2012Article
- Physiology of transition from intrauterine to extrauterine life.Clinics in perinatology · 2012Review
- Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Inflammation and lung maturation from stretch injury in preterm fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIncreased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation.
objectiveWe tested the hypothesis that selective inhibitors of pro-inflammatory signaling would decrease lung inflammation induced by ventilation in preterm newborn lambs. We also examined if the variability in injury response was explained by variations in the endogenous surfactant pool size.
methodsDate-mated preterm lambs (n = 28) were operatively delivered and mechanically ventilated to cause lung injury (tidal volume escalation to 15 mL/kg by 15 min at age). The lambs then were ventilated with 8 mL/kg tidal volume for 1 h 45 min. Groups of animals randomly received specific inhibitors for IL-8, IL-1, or NF-κB. Unventilated lambs (n = 7) were the controls. Bronchoalveolar lavage fluid (BALF) and lung samples were used to quantify inflammation. Saturated phosphatidylcholine (Sat PC) was measured in BALF fluid and the data were stratified based on a level of 5 μmol/kg (~8 mg/kg surfactant).
resultsThe inhibitors did not decrease the cytokine levels or inflammatory response. The inflammation increased as Sat PC pool size in BALF decreased. Ventilated lambs with a Sat PC level > 5 μmol/kg had significantly decreased markers of injury and lung inflammation compared with those lambs with < 5 μmol/kg.
conclusionLung injury caused by high tidal volumes at birth were decreased when endogenous surfactant pool sizes were larger. Attempts to decrease inflammation by blocking IL-8, IL-1 or NF-κB were unsuccessful.
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Registered trials
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