Evidence map›Paper›PMID 21034477›Full record

ArticleGenome biology2010

Rapid haplotype inference for nuclear families.

Amy L Williams, David E Housman, Martin C Rinard, David K Gifford

Abstract readComparative Study
In one paragraph

Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Reconstructing parent genomes using siblings and other relatives.bioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Stable recombination hotspots in birds.Science (New York, N.Y.) · 2015
    Article
  9. Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy L WilliamsComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. amy@csail.mit.edu
David E Housman
Martin C Rinard
David K Gifford

Funding

Transcriptional Regulation of Stem Cell Differentiation into Motor NeuronsP01NS055923 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GIFFORD, DAVID K · 2006 to 2010
$6.6M
Training Program Computational Biology(RMI)T90DK070069 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GIFFORD, DAVID K · 2004 to 2008
$712k
NIDDK NIH HHS 5-T90-DK070069NINDS NIH HHS 5-P01-NS055923
6 · The paper itself

Abstract

Hapi is a new dynamic programming algorithm that ignores uninformative states and state transitions in order to efficiently compute minimum-recombinant and maximum likelihood haplotypes. When applied to a dataset containing 103 families, Hapi performs 3.8 and 320 times faster than state-of-the-art algorithms. Because Hapi infers both minimum-recombinant and maximum likelihood haplotypes and applies to related individuals, the haplotypes it infers are highly accurate over extended genomic distances.

Indexed as

AlgorithmsHaplotypesComputational BiologyDatabases, GeneticGene ConversionGenetic LociGenotypeHumansLikelihood FunctionsModels, GeneticNuclear FamilyPedigreePolymorphism, Single NucleotideSoftware

Identifiers

PMID21034477
PMCPMC3218664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.