ArticleJournal of magnetic resonance imaging : JMRI2010
Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model.
Article in Journal of magnetic resonance imaging : JMRI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Bacterial association with metals enables in vivo monitoring of urogenital microbiota using magnetic resonance imaging.Communications biology · 2024Article
- Tracking of Labelled Stem Cells Using Molecular MR Imaging in a Mouse Burn ModelAdvances in molecular imaging · 2021Article
- Magnetization transfer contrast MRI in GFP‑tagged live bacteria.Molecular medicine reports · 2019Article
- T1ρ Dispersion in Articular Cartilage: Relationship to Material Properties and Macromolecular Content.Cartilage · 2015Article
- MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.NMR in biomedicine · 2013Article
- Imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles.Advances in molecular imaging · 2012Article
Corrections and comments
- Erratum issuedRighi, Valeria [added]
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo develop novel magnetic resonance (MR) imaging methods to monitor accumulation of macrophages in inflammation and infection. Positive-contrast MR imaging provides an alternative to negative-contrast MRI, exploiting the chemical shift induced by ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles to nearby water molecules. We introduce a novel combination of off-resonance (ORI) positive-contrast MRI and T(2ρ) relaxation in the rotating frame (ORI-T(2ρ)) for positive-contrast MR imaging of USPIO. MATERIALS AND
methodsWe tested ORI-T(2ρ) in phantoms and imaged in vivo the accumulation of USPIO-labeled macrophages at the infection site in a mouse model of burn trauma and infection with Pseudomonas aeruginosa (PA). PA infection is clinically important. The USPIO nanoparticles were injected directly in the animals in solution, and macrophage labeling occurred in vivo in the animal model.
resultsWe observed a significant difference between ORI-T(2ρ) and ORI, which leads us to suggest that ORI-T(2ρ) is more sensitive in detecting USPIO signal. To this end, the ORI-T(2ρ) positive contrast method may prove to be of higher utility in future research.
conclusionOur results may have direct implications in the longitudinal monitoring of infection, and open perspectives for testing novel anti-infective compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.