ArticleBrain imaging and behavior2009
Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder.
Article in Brain imaging and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder.Psychiatry research. Neuroimaging · 2021Article
- Serotonin system gene variants and regional brain volume differences in pediatric OCD.Brain imaging and behavior · 2020Article
- Gene-environment interaction: New insights into perceived parenting and social anxiety among adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- An MRI Study of the Metabolic and Structural Abnormalities in Obsessive-Compulsive Disorder.Frontiers in human neuroscience · 2019Article
- Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.The British journal of psychiatry : the journal of mental science · 2018Article
- The importance of the excitatory amino acid transporter 3 (EAAT3).Neurochemistry international · 2016Review
- Whole-genome association analysis of treatment response in obsessive-compulsive disorder.Molecular psychiatry · 2016Article
- The neurobiological link between OCD and ADHD.Attention deficit and hyperactivity disorders · 2014Review
- A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression.Psychopharmacology · 2014Article
- An inherited small microdeletion at 15q13.3 in a patient with early-onset obsessive-compulsive disorder.PloS one · 2014Article
- Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms.Psychopharmacology · 2013Article
- Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study.Psychiatry research · 2013Article
- Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2012Article
- The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder.Pharmacology, biochemistry, and behavior · 2012Review
- NEUROBIOLOGICAL EVIDENCE SUPPORTING GLUTAMATE'S ROLE IN PEDIATRIC OBSESSIVE COMPULSIVE DISORDER.Child & adolescent psychopharmacology news · 2010Article
- Imaging-genetics applications in child psychiatry.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Review
- Glutamate and the Treatment of Obsessive-Compulsive Disorder.Psychopharm review : timely reports in psychopharmacology and device-based therapies · 2010Article
- Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder.Psychiatry research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
This pilot study was undertaken to determine if there was a significant association between specific glutamate system genes and regional volumes of interest implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Volumetric magnetic resonance imaging (MRI) and genotyping of 7 polymorphisms in two genes, glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and solute linked carrier, family 1, member 1 (SLC1A1) were conducted in 31 psychotropic-naïve pediatric OCD patients. The rs1805476 variant of GRIN2B was associated with left but not right orbital frontal cortex (OFC) (p=0.04) and right but not left anterior cingulate cortex (ACC) volume (p=0.02). The SLC1A1 rs3056 variant was associated with increased total (p=0.01), left (p=0.02) and right (p=0.02) thalamic volume. These results suggest that GRIN2B and SLC1A1 may be associated with regional volumetric alterations in OFC, ACC, and thalamus in children with OCD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.