ArticleDeutsches Arzteblatt international2010
Unipolar depression: diagnostic and therapeutic recommendations from the current S3/National Clinical Practice Guideline.
Article in Deutsches Arzteblatt international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Resistance training for depression: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychology · 2025Pooled it
- Accuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis.BMJ (Clinical research ed.) · 2021Pooled it
- Systematic Review of Clinical Practice Guidelines for Failed Antidepressant Treatment Response in Major Depressive Disorder, Dysthymia, and Subthreshold Depression in Adults.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Combining Antidepressants in Acute Treatment of Depression: A Meta-Analysis of 38 Studies Including 4511 Patients.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2016Pooled it
- Information and decision-making needs among people with mental disorders: a systematic review of the literature.Health expectations : an international journal of public participation in health care and health policy · 2015Pooled it
- Cost-effectiveness of collaborative care for the treatment of depressive disorders in primary care: a systematic review.PloS one · 2015Pooled it
- Trial
- Trial
- Brief Web-Based Intervention for Depression: Randomized Controlled Trial on Behavioral Activation.Journal of medical Internet research · 2020Trial
- Guideline-based stepped and collaborative care for patients with depression in a cluster-randomised trial.Scientific reports · 2018Trial
- Effectiveness and cost-effectiveness of a guideline-based stepped care model for patients with depression: study protocol of a cluster-randomized controlled trial in routine care.BMC psychiatry · 2014Trial
- [Integrated care for depressive disorders].Der Nervenarzt · 2014Trial
- Review
- A flexible approach to measure care coordination based on patient-sharing networks.BMC medical research methodology · 2024Article
- The PROVIT Study-Effects of Multispecies Probiotic Add-on Treatment on Metabolomics in Major Depressive Disorder-A Randomized, Placebo-Controlled Trial.Metabolites · 2022Article
- Acceptance and Commitment Therapy for Major Depressive Disorder: Insights into a New Generation of Face-to-Face Treatment and Digital Self-Help Approaches.Advances in experimental medicine and biology · 2021Article
- Observational
- Employers With Metabolic Syndrome and Increased Depression/Anxiety Severity Profit Most From Structured Exercise Intervention for Work Ability and Quality of Life.Frontiers in psychiatry · 2020Article
- Integrating Patients' Expectations into the Management of Their Depression: Report of a Symposium at the European College of Neuropsychopharmacology Congress.Advances in therapy · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepressive disorders are among the most common illnesses and reasons for obtaining health care. Their diagnosis and treatment are still in need of improvement. In Germany, a new S3/National Clinical Practice Guideline has been developed for this purpose.
methodsThe existing guidelines on unipolar depression from Germany and other countries were synoptically compared and supplemented with systematic literature searches. After 14 consensus conferences, a total of 107 evidence-based recommendations were issued.
resultsUnipolar depression should be diagnosed in accordance with ICD-10 criteria. Screening questionnaires are useful aids to diagnostic classification. When a treatment is chosen, shared decision-making with the patient is essential. Mild depressive episodes can be treated initially by watchful waiting for 14 days. For moderate depressive episodes, pharmacotherapy and psychotherapy are equally effective treatment options. For severe depression, a combination of pharmacotherapy and psychotherapy is recommended. If 4 to 6 weeks of acute therapy are insufficiently effective, lithium augmentation is recommended, rather than combination antidepressant therapy or a switch to another antidepressant. After remission, maintenance therapy should be continued for 4 to 9 months. In recurrent depression, pharmacotherapy and/or psychotherapy, where appropriate, should be continued for at least two years. Specific recommendations are given for patients who have somatic or mental comorbidities or are acutely suicidal, and recommendations are also given for coordination of care.
conclusionThis guideline is a comprehensive set of evidence- and consensus-based recommendations for the diagnosis and treatment of unipolar depression. An improvement in the care of patients with unipolar depression will require broad implementation of the guideline, both in the inpatient and outpatient setting.
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Registered trials
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