Evidence map›Paper›PMID 21030969›Full record

ArticleKidney international2010

Adaptation of intercalated cells along the collecting duct to systemic acid/base changes.

John H Schwartz, Edward A Alexander

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The HAmerican journal of physiology. Cell physiology · 2021
    Review
  2. Maintaining KAmerican journal of physiology. Renal physiology · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

John H SchwartzRenal Section, Boston University Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA. jhsch@bu.edu
Edward A Alexander

Funding

SNAREs In The Trafficking Of IMCD H+-Atpase And AQP2R01DK059529 · NIDDK · BOSTON MEDICAL CENTER · PI SCHWARTZ, JOHN H · 2002 to 2011
$3.2M
NIDDK NIH HHS DK59529
6 · The paper itself

Abstract

Collecting duct intercalated cells respond to short-term acid/base perturbations by rapidly shuttling H(+)-ATPase to and from the plasma membrane. Purkerson et al. provide information on the regulation of the anion transporters during chronic acidosis and acute recovery (alkalosis). They found that the major mechanism for both acute and chronic states is regulation of both the H(+)-ATPase and the anion exchangers plus changes in the overall expression level of these anion transporters in chronic adaptation.

Indexed as

Acid-Base EquilibriumAcidosisAdaptation, PhysiologicalAlkalosisAnimalsAnion Exchange Protein 1, ErythrocyteAnion Transport ProteinsKidney Tubules, CollectingMembrane Transport ProteinsModels, AnimalProton-Translocating ATPasesRabbitsAnion Exchange Protein 1, ErythrocyteAnion Transport ProteinsMembrane Transport ProteinsProton-Translocating ATPases

Identifiers

PMID21030969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.