ArticleNature protocols2010
Distinguishing cell types or populations based on the computational analysis of their infrared spectra.
Article in Nature protocols, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed.
- Differential diagnosis of Alzheimer's disease using spectrochemical analysis of blood.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Optical convolutional spectrometer.Nature photonics · 2026Article
- Waveguide Spectroscopy for Differentiation of Bacteria.Analytical chemistry · 2025Article
- Toward Informative Representations of Blood-Based Infrared Spectra via Unsupervised Deep Learning.Journal of biophotonics · 2025Article
- Bridging Spectral Gaps: Cross-Device Model Generalization in Blood-Based Infrared Spectroscopy.Analytical chemistry · 2025Article
- Optical Photothermal Infrared Imaging Using Metabolic Probes in Biological Systems.Analytical chemistry · 2025Article
- AI-Assisted Detection for Early Screening of Acute Myeloid Leukemia Using Infrared Spectra and Clinical Biochemical Reports of Blood.Bioengineering (Basel, Switzerland) · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Raman Spectroscopy Detects Bone Mineral Changes with Aging in Archaeological Human Lumbar Vertebrae from Thornton Abbey.Applied spectroscopy · 2025Article
- Spectrochemical differentiation in endometriosis based on infrared spectroscopy advanced data fusion and multivariate analysis.Scientific reports · 2025Article
- Open-set deep learning-enabled single-cell Raman spectroscopy for rapid identification of airborne pathogens in real-world environments.Science advances · 2025Article
- The Perils of Molecular Interpretations from Vibrational Spectra of Complex Samples.Angewandte Chemie (International ed. in English) · 2024Review
- Salivary detection of Chikungunya virus infection using a portable and sustainable biophotonic platform coupled with artificial intelligence algorithms.Scientific reports · 2024Article
- Attenuated total reflection Fourier-transform infrared spectroscopy reveals environment specific phenotypes in clonal Japanese knotweed.BMC plant biology · 2024Article
- Plasma infrared fingerprinting with machine learning enables single-measurement multi-phenotype health screening.Cell reports. Medicine · 2024Article
- Effects of Benzo (ACS omega · 2024Article
- Article
- Point-of-Care Disease Screening in Primary Care Using Saliva: A Biospectroscopy Approach for Lung Cancer and Prostate Cancer.Journal of personalized medicine · 2023Article
- Translating Biospectroscopy Techniques to Clinical Settings: A New Paradigm in Point-of-Care Screening and/or Diagnostics.Journal of personalized medicine · 2023Article
- ATR-FTIR Spectroscopy with Chemometrics for Analysis of Saliva Samples Obtained in a Lung-Cancer-Screening Programme: Application of Swabs as a Paradigm for High Throughput in a Clinical Setting.Journal of personalized medicine · 2023Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Infrared (IR) spectroscopy of intact cells results in a fingerprint of their biochemistry in the form of an IR spectrum; this has given rise to the new field of biospectroscopy. This protocol describes sample preparation (a tissue section or cytology specimen), the application of IR spectroscopy tools, and computational analysis. Experimental considerations include optimization of specimen preparation, objective acquisition of a sufficient number of spectra, linking of the derived spectra with tissue architecture or cell type, and computational analysis. The preparation of multiple specimens (up to 50) takes 8 h; the interrogation of a tissue section can take up to 6 h (∼100 spectra); and cytology analysis (n = 50, 10 spectra per specimen) takes 14 h. IR spectroscopy generates complex data sets and analyses are best when initially based on a multivariate approach (principal component analysis with or without linear discriminant analysis). This results in the identification of class clustering as well as class-specific chemical entities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.