ArticleObesity (Silver Spring, Md.)2011
Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents.
Article in Obesity (Silver Spring, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Comparison of the effect of Roux-en-Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Enteroendocrine Reprogramming by Altered Epithelial-Mesenchymal Crosstalk in Metabolic Surgery.Journal of metabolic and bariatric surgery · 2024Review
- Bile acids and metabolic surgery.Liver research (Beijing, China) · 2021Review
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
- A rodent model of partial intestinal diversion: a novel metabolic operation.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020Article
- Intestinal and Gastric Origins for Diabetes Resolution After Bariatric Surgery.Current obesity reports · 2018Review
- Duodeno-jejunal bypass restores β-cell hypersecretion and islet hypertrophy in western diet obese rats.Endocrine · 2018Article
- Early Weight Loss Independent Effects of Sleeve Gastrectomy on Diet-Induced Cardiac Dysfunction in Obese, Wistar Rats.Obesity surgery · 2017Article
- Bile acids and bariatric surgery.Molecular aspects of medicine · 2017Review
- Recent advances in metabolic and bariatric surgery.F1000Research · 2016Review
- Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue.Obesity surgery · 2015Article
- Roux-en Y gastric bypass is superior to duodeno-jejunal bypass in improving glycaemic control in Zucker diabetic fatty rats.Obesity surgery · 2014Article
- Intestinal sweet-sensing pathways and metabolic changes after Roux-en-Y gastric bypass surgery.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Review
- Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.Diabetes · 2013Article
- Mouse Models of Bariatric Surgery.Current protocols in mouse biology · 2012Article
- Effects of bariatric surgery on glucose homeostasis and type 2 diabetes.Gastroenterology · 2012Review
- New clues to bariatric surgery's benefits.Nature medicine · 2012Article
- Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes.Obesity (Silver Spring, Md.) · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Roux-en-y gastric bypass (RYGB) surgery rapidly improves glucose tolerance and reverses insulin resistance in obese patients. It has been hypothesized that this effect is mediated by the diversion of nutrients from the proximal small intestine. We utilized duodenal-jejunal bypass (DJB) as a modification of gastric bypass to determine the effect of nutrient diversion from the foregut without gastric restriction on insulin resistance in obese rats. The effects of DJB or Sham surgery on glucose homeostasis were determined in both high-fat-fed Long-Evans and Wistar rats. Body weight and food intake were measured weekly postoperatively, and body composition was monitored before and after surgery. Glucose tolerance was tested before and as early as 1 month postoperation; additionally, in Wistar rats, insulin sensitivity was determined by a hyperinsulinemic-euglycemic clamp (HIEC). DJB did not affect body weight, body composition, glucose tolerance, or insulin concentrations over the period of the study. The average glucose infusion rate (GIR) during the HIEC was 6.2 ± 1.16 mg/kg/min for Sham rats compared to 7.2 ± 1.71 mg/kg/min for DJB rats (P = 0.62), and neither endogenous glucose production (EGP; P = 0.81) nor glucose utilization (glucose disappearance (R(d)), P = 0.59) differed between DJB and Sham rats. DJB does not affect insulin resistance induced by a high-fat diet in Long-Evans and Wistar rats. These data suggest that duodenal bypass alone is an insufficient mechanism to alter insulin sensitivity independent of weight loss in obese, nondiabetic rodents.
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