ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011
Mechanisms regulating muscle mass during disuse atrophy and rehabilitation in humans.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03670693 (Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Anabolic Androgenic Steroids in Orthopaedic Surgery: Current Concepts and Clinical Applications.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Pooled it
- Exercise for cancer cachexia in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Effects of blood flow restriction on muscle size and gene expression in muscle during immobilization: A pilot study.Physiological reports · 2020Trial
- Unilateral strength training leads to muscle-specific sparing effects during opposite homologous limb immobilization.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Trial
- Effects of 2 weeks lower limb immobilization and two separate rehabilitation regimens on gastrocnemius muscle protein turnover signaling and normalization genes.BMC research notes · 2012Trial
- 5-Fluorouracil-based chemotherapy disrupts autophagy flux and protein synthesis in cultured myotubes: a role for mTORC1 signaling.American journal of physiology. Cell physiology · 2026Article
- Molecular interaction mechanisms of muscle fiber type transition in aging sarcopenia and the role of exercise intervention.The Egyptian journal of internal medicine · 2026Article
- Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training.Sports medicine and health science · 2025Review
- Electrical Stimulation Prevents Muscular Atrophy and the Decrease of Interleukin-6 in Paralyzed Muscles after Spinal Cord Injury in Rats.Revista brasileira de ortopedia · 2024Article
- Article
- Effectiveness of an On-Field Rehabilitation framework for return to sports in injured male professional football players: a single-blinded, prospective, randomised controlled trial.BMJ open sport & exercise medicine · 2024Article
- Shared and distinct mechanisms of skeletal muscle atrophy: A narrative review.Ageing research reviews · 2021Review
- Wheel running improves fasting-induced AMPK signaling in skeletal muscle from tumor-bearing mice.Physiological reports · 2021Article
- Acromioclavicular Joint Injuries: Effective Rehabilitation.Open access journal of sports medicine · 2021Review
- Redox Control of Proteolysis During Inactivity-Induced Skeletal Muscle Atrophy.Antioxidants & redox signaling · 2020Review
- Transcriptional changes in muscle of hibernating arctic ground squirrels (Urocitellus parryii): implications for attenuation of disuse muscle atrophy.Scientific reports · 2020Article
- Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.Skeletal muscle · 2020Article
- Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy.PloS one · 2020Article
- Local low-intensity vibration improves healing of muscle injury in mice.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle mass loss accompanies periods of bedrest and limb immobilization in humans and requires rehabilitation exercise to effectively restore mass and function. Although recent evidence points to an early and transient rise in muscle protein breakdown contributing to this decline in muscle mass, the driving factor seems to be a reduction in muscle protein synthesis, not least in part due to the development of anabolic resistance to amino acid provision. Although the AKT signaling pathway has been identified in small animals as central to the regulation of muscle protein synthesis, several studies in humans have now demonstrated a disassociation between AKT signaling and muscle protein synthesis during feeding, exercise, and immobilization, suggesting that the mechanisms regulating protein synthesis in human skeletal muscle are more complex than initially thought (at least in non-inflammatory states). During rehabilitation, exercise-induced myogenesis may in part be responsible for the recovery of muscle mass. Rapid and sustained exercise-induced suppression of myostatin mRNA expression, that precedes any gain in muscle mass, points to this, along with other myogenic proteins, as being potential regulators of muscle regeneration during exercise rehabilitation in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.