ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011
Variability in training-induced skeletal muscle adaptation.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effects of Dietary Protein Supplementation on Acute Changes in Muscle Protein Synthesis and Longer-Term Changes in Muscle Mass, Strength, and Aerobic Capacity in Response to Concurrent Resistance and Endurance Exercise in Healthy Adults: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- A Systematic Review and Meta-Analysis on the Longitudinal Effects of Unilateral Knee Extension Exercise on Muscle Strength.Frontiers in sports and active living · 2020Pooled it
- Trial
- Strength gains after 12 weeks of resistance training correlate with neurochemical markers of brain health in older adults: a randomized controlGeroScience · 2023Trial
- Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.Cell reports · 2020Trial
- Trial
- Aerobic exercise augments muscle transcriptome profile of resistance exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Heterogeneity of physical function responses to exercise training in older adults.Journal of the American Geriatrics Society · 2015Trial
- Effects of mild-exercise training cessation in human skeletal muscle.European journal of applied physiology · 2012Trial
- Evaluating the Return on Investment of U.S. Army Holistic Health and Fitness Performance Teams: A Matched Difference-in-Differences Study of Readiness and Economic Outcomes.Sports medicine (Auckland, N.Z.) · 2026Article
- Review
- Impact of resistance and high-intensity interval training on body composition, physical function, and temporal dynamics of adaptation in older women with impaired cardiometabolic health: a randomized clinical trial.BMC sports science, medicine & rehabilitation · 2025Article
- Rate of Perceived Exertion Based on Repetitions in Reserve Versus Percentage of One-Repetition Maximum for Resistance Training Prescription in Cardiac Rehabilitation: A Pilot Study.Journal of cardiovascular development and disease · 2024Article
- Genetic Determinants of Endurance: A Narrative Review on Elite Athlete Status and Performance.International journal of molecular sciences · 2024Review
- Molecular predictors of resistance training outcomes in young untrained female adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Commentaries on Viewpoint: Hoping for the best, prepared for the worst: can we perform remote data collection in sport sciences?Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- An appetite for growth: The role of the hypothalamic - pituitary - growth hormone axis in energy balance.Journal of neuroendocrinology · 2022Review
- Endurance-exercise training adaptations in spinal motoneurones: potential functional relevance to locomotor output and assessment in humans.European journal of applied physiology · 2022Review
- Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?Biomedicines · 2022Review
- Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When human skeletal muscle is exposed to exercise training, the outcomes, in terms of physiological adaptation, are unpredictable. The significance of this fact has long been underappreciated, and only recently has progress been made in identifying some of the molecular bases for the heterogeneous response to exercise training. It is not only of great medical importance that some individuals do not substantially physiologically adapt to exercise training, but the study of the heterogeneity itself provides a powerful opportunity to dissect out the genetic and environmental factors that limit adaptation, directly in humans. In the following review I will discuss new developments linking genetic and transcript abundance variability to an individual's potential to improve their aerobic capacity or endurance performance or induce muscle hypertrophy. I will also comment on the idea that certain gene networks may be associated with muscle "adaptability" regardless the stimulus provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.