Evidence map›Paper›PMID 21030603›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010

Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q.

Shenying Fang, Susan M Pinney, Joan E Bailey-Wilson, Mariza A de Andrade, Yafang Li, Elena Kupert, Ming You, Ann G Schwartz, Ping Yang, Marshall W Anderson and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02295085 (Fernald Community Cohort - 18 Year Observational Study with Bio Banked Blood and Urine Samples), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02295085 unknown statusnot on this map

Fernald Community Cohort - 18 Year Observational Study with Bio Banked Blood and Urine Samples

TypeobservationalSponsorUniversity of CincinnatiRan1990 to 2025Enrolled9,782ConditionsCancer, Renal Failure, Diabetes, Cardiovascular Disease
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Putative linkage signals identified for breast cancer in African American families.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015
    Trial
  2. Article
  3. Article
  4. Germline mutations causing familial lung cancer.Journal of human genetics · 2015
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Shenying FangDepartment of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Susan M Pinney
Joan E Bailey-Wilson
Mariza A de Andrade
Yafang Li
Elena Kupert
Ming You
Ann G Schwartz
Ping Yang
Marshall W Anderson
Christopher I Amos
University of Cincinnati · USThe University of Texas MD Anderson Cancer Center · USWashington University in St. Louis · USMayo Clinic · USWayne State University · US

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4M
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Pilot Project ProgramP30ES007784 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RICHIE, ELLEN R · 1996 to 2011
$16.4M
Genetic Epidemiology of CancerZIAHG200331 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$11.7M
GENETIC EPIDEMIOLOGY OF LUNG CANCERU01CA076293 · NCI · UNIVERSITY OF CINCINNATI · PI ANDERSON, MARSHALL W · 1999 to 2009
$11.5M
Transdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9M
GENETIC EPIDEMIOLOGY OF LUNG CANCERR01CA060691 · NCI · WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · 1995 to 2009
$6.2M
High Density Association Analysis of Lung CancerR01CA121197 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2010
$3.0M
Adenocarinoma of the Lung in WomenR01CA087895 · NCI · WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G · 2001 to 2005
$3.0M
Statistical Methods for Gene Environment Interactions In Lung CancerR01CA133996 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2009
$790k
Intramural NIH HHSNCI NIH HHS N01 PC035145NCI NIH HHS P30CA016772NCI NIH HHS P50 CA070907NCI NIH HHS P50CA70907NCI NIH HHS R01 CA060691NCI NIH HHS R01CA060691NCI NIH HHS R01 CA087895NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA133996NCI NIH HHS R01CA133996NCI NIH HHS R01CA87895NCI NIH HHS U01 CA076293NCI NIH HHS U19 CA148127NCI NIH HHS UO1CA076293NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES007784NIEHS NIH HHS P30ES007784NIEHS NIH HHS P30ES007789NIEHS NIH HHS P30ES06096
6 · The paper itself

Abstract

backgroundGenetic susceptibility for cancer can differ substantially among families. We use trait-related covariates to identify a genetically homogeneous subset of families with the best evidence for linkage in the presence of heterogeneity.

methodsWe performed a genome-wide linkage screen in 93 families. Samples and data were collected by the familial lung cancer recruitment sites of the Genetic Epidemiology of Lung Cancer Consortium. We estimated linkage scores for each family by the Markov chain Monte Carlo procedure using SimWalk2 software. We used ordered subset analysis (OSA) to identify genetically homogenous families by ordering families based on a disease-associated covariate. We performed permutation tests to determine the relationship between the trait-related covariate and the evidence for linkage.

resultsA genome-wide screen for lung cancer loci identified strong evidence for linkage to 6q23-25 and suggestive evidence for linkage to 12q24 using OSA, with peak logarithm of odds (LOD) scores of 4.19 and 2.79, respectively. We found other chromosomes also suggestive for linkages, including 5q31-q33, 14q11, and 16q24.

conclusionsOur OSA results support 6q as a lung cancer susceptibility locus and provide evidence for disease linkage on 12q24. This study further increased our understanding of the inheritability for lung cancer. Validation studies using larger sample size are needed to verify the presence of several other chromosomal regions suggestive of an increased risk for lung cancer and/or other cancers. IMPACT: OSA can reduce genetic heterogeneity in linkage study and may assist in revealing novel susceptibility loci.

Indexed as

Chromosomes, Human, Pair 12Chromosomes, Human, Pair 6FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLod ScoreLung NeoplasmsMaleMiddle AgedRisk Factors

Identifiers

PMID21030603
PMCPMC3249234
OpenAlexW2136093513

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.