ArticleJournal of the American Society of Nephrology : JASN2010
Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia.
Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Repurposing minocycline as an added-on treatment for ulcerative colitis patients on mesalamine: a randomized clinical pilot study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Managing hyponatremia: fast or slow? Why, when, how, and controversies.Clinical kidney journal · 2026Review
- NFE2L2 suppresses microglia-mediated neuroinflammation to preserve neuronal dendritic architecture from cadmium-induced damage.Cell biology and toxicology · 2026Article
- Differential expression of genes involved in the chronic response to intracortical microelectrodes.Acta biomaterialia · 2023Article
- Adaptation of the Brain to Hyponatremia and Its Clinical Implications.Journal of clinical medicine · 2023Review
- Article
- Pediatric osmotic demyelination syndrome in a case of type 1 diabetes mellitus with diabetic ketoacidosis.Clinical case reports · 2022Article
- Delayed Minocycline Treatment Ameliorates Hydrocephalus Development and Choroid Plexus Inflammation in Spontaneously Hypertensive Rats.International journal of molecular sciences · 2022Article
- Alcoholic pontine myelinolysis: beware the stroke mimic.BJR case reports · 2021Article
- A Case of Osmotic Demyelination Syndrome in a Chronic Alcoholic With Moderate Hyponatremia.Cureus · 2021Article
- Osmotic Demyelination Syndrome due to Rhabdomyolysis and Hyperosmolar Hyperglycemic Syndrome following Cardiogenic Shock.Case reports in critical care · 2021Article
- Central pontine myelinolysis during treatment of hyperglycemic hyperosmolar syndrome: a case report.Clinical diabetes and endocrinology · 2020Article
- IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum.Brain pathology (Zurich, Switzerland) · 2020Article
- Osmotic Demyelination: From an Oligodendrocyte to an Astrocyte Perspective.International journal of molecular sciences · 2019Review
- Opinion: An Existing Drug to AssessFrontiers in pharmacology · 2019Article
- Therapeutic Effect of Steroids in Osmotic Demyelination of Infancy.Child neurology open · 2018Article
- TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination.Frontiers in cellular neuroscience · 2018Article
- The Improvement of the Outcome of Osmotic Demyelination Syndrome by Plasma Exchange.Internal medicine (Tokyo, Japan) · 2017Article
- The utility and accuracy of four equations in predicting sodium levels in dysnatremic patients.Clinical kidney journal · 2016Article
- Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.Journal of the American Society of Nephrology : JASN · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid correction of chronic hyponatremia can lead to osmotic demyelination syndrome (ODS), a severe demyelination disease. The microglia that accumulate in the demyelinative lesions may play a detrimental role in the pathogenesis of ODS by producing proinflammatory cytokines, suggesting that they may be a target for therapeutic intervention. Here, we investigated whether minocycline, a selective and potent inhibitor of microglial activation, could protect against ODS in rats. We induced hyponatremia by liquid diet feeding and dDAVP infusion. Rapid correction of the hyponatremia 7 days later resulted in neurologic impairment with severe demyelinative lesions. Activated microglia accumulated at the site of demyelination. Treatment with minocycline within 24 hours of rapid correction, however, was protective: rats exhibited minimal neurologic impairment, and survival improved. Histologic analysis showed that minocycline inhibited demyelination and suppressed the accumulation of microglia at the site of demyelination. Real-time RT-PCR and immunohistochemical analyses showed that minocycline inhibited the activity of microglia and the expression of inflammatory cytokines (e.g. IL-1β, inducible nitric-oxide synthase, and TNF-α), monocyte chemoattractant protein-1, and matrix metalloproteinase-12 in microglia. These results demonstrate that minocycline can protect against ODS by inhibiting the activation and accumulation of microglia at the site of demyelinative lesions, suggesting its possible use in clinical practice.
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