ArticleLearning & memory (Cold Spring Harbor, N.Y.)2010
Central cannabinoid receptors modulate acquisition of eyeblink conditioning.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Loss of dystrophin reduces CB1 receptor expression and endocannabinoid-dependent synaptic plasticity in the cerebellar cortex.bioRxiv : the preprint server for biology · 2026Article
- Three principles for the utility of simple tasks that assess elemental processes in parsing heterogeneity.Journal of psychopathology and clinical science · 2024Article
- Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.Nature communications · 2021Article
- Differential effects of two early life stress paradigms on cerebellar-dependent delay eyeblink conditioning.Neurobiology of stress · 2020Article
- Cannabinoids modulate associative cerebellar learning via alterations in behavioral state.eLife · 2020Article
- Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress.Scientific reports · 2020Article
- Cannabinoid agonist administration within the cerebellar cortex impairs motor learning.Neurobiology of learning and memory · 2020Review
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning.Behavioural brain research · 2020Article
- Long-term depression of presynaptic cannabinoid receptor function at parallel fibre synapses.The Journal of physiology · 2019Article
- Cannabinoid modulation of memory consolidation within the cerebellum.Neurobiology of learning and memory · 2016Article
- Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia?The Journal of physiology · 2016Review
- Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Differential effects of the cannabinoid agonist WIN55,212-2 on delay and trace eyeblink conditioning.Behavioral neuroscience · 2013Article
- Examining the effects of former cannabis use on cerebellum-dependent eyeblink conditioning in humans.Psychopharmacology · 2012Article
- Evaluation of bidirectional interstimulus interval (ISI) shift in auditory delay eye-blink conditioning in healthy humans.Learning & behavior · 2011Article
- Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Delay eyeblink conditioning is established by paired presentations of a conditioned stimulus (CS) such as a tone or light, and an unconditioned stimulus (US) that elicits the blink reflex. Conditioned stimulus information is projected from the basilar pontine nuclei to the cerebellar interpositus nucleus and cortex. The cerebellar cortex, particularly the molecular layer, contains a high density of cannabinoid receptors (CB1R). The CB1Rs are located on the axon terminals of parallel fibers, stellate cells, and basket cells where they inhibit neurotransmitter release. The present study examined the effects of a CB1R agonist WIN55,212-2 and antagonist SR141716A on the acquisition of delay eyeblink conditioning in rats. Rats were given subcutaneous administration of 1, 2, or 3 mg/kg of WIN55,212-2 or 1, 3, or 5 mg/kg of SR141716A before each day of acquisition training (10 sessions). Dose-dependent impairments in acquisition were found for WIN55,212-2 and SR141716A, with no effects on spontaneous or nonassociative blinking. However, the magnitude of impairment was greater for WIN55,212-2 than SR141716A. Dose-dependent impairments in conditioned blink response (CR) amplitude and timing were found with WIN55,212-2 but not with SR141716A. The findings support the hypothesis that CB1Rs in the cerebellar cortex play an important role in plasticity mechanisms underlying eyeblink conditioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.