ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Diastolic blood pressure levels and ischemic stroke incidence in older adults with white matter lesions.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Identification of Distinct Arterial Waveform Clusters and a Longitudinal Evaluation of Their Clinical Usefulness.Hypertension (Dallas, Tex. : 1979) · 2019Trial
- Identification of Ischemic Stroke Patients Based on Plasma Concentrations of Extracellular Vesicles.Translational stroke research · 2025Article
- Prediction of transient ischemic attack and minor stroke in people with type 2 diabetes mellitus.Journal of diabetes and its complications · 2021Article
- Lower Blood Pressure and Gray Matter Integrity Loss in Older Persons.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span.PloS one · 2013Article
- Intrinsic association of widowhood with mortality in community-dwelling older women and men: findings from a prospective propensity-matched population study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Connecting cerebral white matter lesions and hypertensive target organ damage.Journal of aging research · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe optimal blood pressure level to minimize the risk of ischemic stroke (IS) in older adults is undetermined. Cerebral white matter lesions (WML), prevalent in older adults, may be a marker for vulnerability to IS. We aimed at determining the relationship between diastolic blood pressure (DBP) levels and IS in the presence of WML.
methodsThe Cardiovascular Health Study population (N = 3,345, age ≥ 65 years, N = 3,345) was followed between 1989 and 2002 for IS incidence. Survival analysis included quintiles of DBP analyzed within WML levels controlling for age and cardiovascular disease.
resultsDBP had no effect on IS incidence in low WML levels but had a marginally significant J-curve relationship with IS in high WML levels: the adjusted hazard ratio for IS in the lowest (<63 mmHg) and highest (≥ 80) DBP quintiles compared with the third (nadir, 69-73 mmHg) was 1.64 (95% confidence interval: 0.93-2.9) and 1.83 (95% confidence interval: 1.06-3.15), respectively.
conclusionsIn older adults with low-grade WML, low DBP may not pose a risk for IS. However, in high-grade WML, IS risk may increase in DBP less than 69 mmHg but is highest more than 80 mmHg. People with high-grade WML may be at risk of IS in high and low DBP.
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