ArticleEmerging infectious diseases2010
Lymphotropism of Merkel cell polyomavirus infection, Nova Scotia, Canada.
Article in Emerging infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Predominant Merkel Cell Polyomavirus DNA Detection in Essential Thrombocythemia within Myeloproliferative Neoplasms.Cancer research communications · 2026Article
- Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer.Molecular oncology · 2026Article
- Review
- Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus.New microbes and new infections · 2024Article
- Review
- Emerging role of human polyomaviruses 6 and 7 in human cancers.Infectious agents and cancer · 2021Review
- Review
- Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors.Thoracic cancer · 2019Article
- Human polyomaviruses and cancer: an overview.Clinics (Sao Paulo, Brazil) · 2018Review
- Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40.PloS one · 2018Article
- Viral Oncology: Molecular Biology and Pathogenesis.Journal of clinical medicine · 2017Review
- Exposure to raccoon polyomavirus (RacPyV) in free-ranging North American raccoons (Procyon lotor).Virology · 2016Article
- Detection of human polyomavirus 7 in human thymic epithelial tumors.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Article
- Review
- Identification of a novel human polyomavirus in organs of the gastrointestinal tract.PloS one · 2013Article
- MCV and Merkel cell carcinoma: a molecular success story.Current opinion in virology · 2012Review
- Novel human polyomaviruses, Merkel cell polyomavirus and human polyomavirus 9, in Japanese chronic lymphocytic leukemia cases.Journal of hematology & oncology · 2012Article
- Merkel cell carcinoma: a virus-induced human cancer.Annual review of pathology · 2012Review
- Human polyomaviruses in skin diseases.Pathology research international · 2011Article
- Vulvar merkel carcinoma: a case report.Case reports in medicine · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.