ArticleGenes, brain, and behavior2011
OPRM1 gene variants modulate amphetamine-induced euphoria in humans.
Article in Genes, brain, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction.Scientific reports · 2020Trial
- Opioids and social bonding: naltrexone reduces feelings of social connection.Social cognitive and affective neuroscience · 2016Trial
- Effects of amphetamine on the human brain opioid system--a positron emission tomography study.The international journal of neuropsychopharmacology · 2013Trial
- Candidate gene studies of a promising intermediate phenotype: failure to replicate.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- The amphetamine response moderates the relationship between negative emotionality and alcohol use.Alcoholism, clinical and experimental research · 2013Trial
- COMT Val158Met, BDNF Val66Met, and OPRM1 Asn40Asp and methamphetamine dependence treatment response: preliminary investigation.Journal of clinical psychopharmacology · 2012Trial
- The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.Current pain and headache reports · 2026Review
- Mu opioid receptor gene variant modulates subjective response to smoked cannabis.American journal of translational research · 2022Article
- Identification of a sex-stratified genetic algorithm for opioid addiction risk.The pharmacogenomics journal · 2021Article
- Genetic Vulnerability to Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Subjective responses predict d-amphetamine choice in healthy volunteers.Pharmacology, biochemistry, and behavior · 2021Article
- Opioid receptors: drivers to addiction?Nature reviews. Neuroscience · 2018Review
- Verification of a genetic locus for methamphetamine intake and the impact of morphine.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- The frequency ofAnnals of general psychiatry · 2018Article
- Sweet taste pleasantness is modulated by morphine and naltrexone.Psychopharmacology · 2016Article
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- Prenatal exposure to cigarette smoke interacts with OPRM1 to modulate dietary preference for fat.Journal of psychiatry & neuroscience : JPN · 2015Article
- Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth.Brain and behavior · 2014Article
- Opioid receptor mu 1 gene, fat intake and obesity in adolescence.Molecular psychiatry · 2014Article
- Low- and high-cocaine locomotor responding rats differ in reinstatement of cocaine seeking and striatal mGluR5 protein expression.Neuropharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The μ-opioid receptor is involved in the rewarding effects of not only opioids like morphine but also psychostimulants like amphetamine. This study aimed to investigate associations between subjective response to amphetamine and genetic polymorphisms and haplotypes in the μ-opioid receptor including the exonic variant rs1799971 (Asp40Asn). One hundred and sixty-two Caucasian volunteers participated in three sessions receiving either placebo or d-amphetamine (10 and 20 mg). Associations between levels of self-reported Euphoria, Energy and Stimulation [Addiction Research Center Inventory 49-item questionnaire (ARCI-49)] after d-amphetamine ingestion and polymorphisms in OPRM1 were investigated. The intronic single nucleotide polymorphisms (SNPs) rs510769 and rs2281617 were associated with significantly higher ratings of Euphoria, Energy and Stimulation after 10 mg amphetamine. Feelings of Euphoria, Energy and Stimulation were also found to be associated with a two-SNP haplotype formed with rs1799971 and rs510769 and a three-SNP haplotype formed with rs1918760, rs2281617 and rs1998220. These results support the hypothesis that genetic variability in the μ-opioid receptor gene influences the subjective effects of amphetamine and may suggest new strategies for prevention and treatment of psychostimulant abuse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.