ArticleBiomacromolecules2010
Development of macroporous poly(ethylene glycol) hydrogel arrays within microfluidic channels.
Article in Biomacromolecules, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 112 citations in OpenAlex.
- Catalytically controlled formation of coumarin-based hydrogelator enables colorimetric ferrous ion detection in sol and hydrogel.Communications chemistry · 2025Article
- Nanoparticle-Reinforced Hydrogel with a Well-Defined Pore Structure for Sustainable Drug Release and Effective Wound Healing.ACS applied bio materials · 2025Article
- Selective Adsorption of Ionic Species Using Macroporous Monodispersed Polyethylene Glycol Diacrylate/Acrylic Acid Microgels with Tunable Negative Charge.Gels (Basel, Switzerland) · 2023Article
- Plug-and-play fiber-optic sensors based on engineered cells for neurochemical monitoring at high specificity in freely moving animals.Science advances · 2023Article
- Remote near infrared identification of pathogens with multiplexed nanosensors.Nature communications · 2020Article
- Microfluidic In-Situ Measurement of Poisson's Ratio of Hydrogels.Micromachines · 2020Article
- Laterally Aggregated Polyacrylamide Gels for Immunoprobed Isoelectric Focusing.Analytical chemistry · 2020Article
- Affinity-Enhanced CTC-Capturing Hydrogel Microparticles Fabricated by Degassed Mold Lithography.Journal of clinical medicine · 2020Article
- Engineering functional hydrogel microparticle interfaces by controlled oxygen-inhibited photopolymerization.Colloids and surfaces. B, Biointerfaces · 2019Article
- Macroporous Hydrogels for Stable Sequestration and Sustained Release of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Using Nucleic Acid Aptamers.ACS biomaterials science & engineering · 2019Article
- Preparation of Xylan-Polymers · 2019Article
- Xylan-Based Hydrogels as a Potential Carrier for Drug Delivery: Effect of Pore-Forming Agents.Pharmaceutics · 2018Article
- Application of Millifluidics to Encapsulate and Support Viable Human Mesenchymal Stem Cells in a Polysaccharide Hydrogel.International journal of molecular sciences · 2018Article
- Digital Manufacturing of Selective Porous Barriers in Microchannels Using Multi-Material Stereolithography.Micromachines · 2018Article
- Fluorescent hydrogel waveguide for on-site detection of heavy metal ions.Scientific reports · 2017Article
- Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors.Microsystems & nanoengineering · 2017Article
- Polysaccharide Hydrogels Support the Long-Term Viability of Encapsulated Human Mesenchymal Stem Cells and Their Ability to Secrete Immunomodulatory Factors.Stem cells international · 2017Article
- Resilin-PEG Hybrid Hydrogels Yield Degradable Elastomeric Scaffolds with Heterogeneous Microstructure.Biomacromolecules · 2016Article
- Hydrogel microparticles for biosensing.European polymer journal · 2015Article
- Use of Cross-Linked Poly(ethylene glycol)-Based Hydrogels for Protein Crystallization.Crystal growth & design · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mass transport of solutes through hydrogels is an important design consideration in materials used for tissue engineering, drug delivery, and protein arrays used to quantify protein concentration and activity. We investigated the use of poly(ethylene glycol) (PEG) as a porogen to enhance diffusion of macromolecules into the interior of polyacrylamide and PEG hydrogel posts photopatterned within microfluidic channels. The diffusion of GST-GFP and dextran-FITC into hydrogels was monitored and effective diffusion coefficients were determined by fitting to the Fickian diffusion equations. PEG-diacrylate (M(r) 700) with porogen formed a macroporous structure and permitted significant penetration of 250 kDa dextran. Proteins copolymerized in these macroporous hydrogels retained activity and were more accessible to antibody binding than proteins copolymerized in nonporous gels. These results suggest that hydrogel macroporosity can be tuned to regulate macromolecular transport in applications such as tissue engineering and protein arrays.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.