ArticleChromosoma1990
Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin.
Article in Chromosoma, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 141 citations in OpenAlex.
- Lamin A/C regulates cerebellar granule cell maturation.Cell biology and toxicology · 2025Article
- Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture.PNAS nexus · 2024Article
- Review
- Epigenetics inCells · 2023Review
- Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS.The Journal of cell biology · 2022Article
- Lamin post-translational modifications: emerging toggles of nuclear organization and function.Trends in biochemical sciences · 2021Review
- Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome.Genome medicine · 2020Article
- Distinct 3D Structural Patterns of Lamin A/C Expression in Hodgkin and Reed-Sternberg Cells.Cancers · 2018Article
- The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization.Frontiers in genetics · 2018Review
- The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function.Frontiers in immunology · 2018Review
- Review
- Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy.Molecular biology of the cell · 2015Article
- Nuclear mechanics in cancer.Advances in experimental medicine and biology · 2014Review
- An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.Human molecular genetics · 2011Article
- Reorganization of the nuclear lamina and cytoskeleton in adipogenesis.Histochemistry and cell biology · 2011Article
- Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin.FEBS letters · 2010Article
- "Laminopathies": a wide spectrum of human diseases.Experimental cell research · 2007Review
- Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy.American journal of human genetics · 2006Article
- Coupling of the nucleus and cytoplasm: role of the LINC complex.The Journal of cell biology · 2006Article
- Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells.The Journal of cell biology · 2000Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous analyses of the nuclear lamina of mammalian cells have revealed three major protein components (lamins A, B and C) that have been identified by protein sequence homology as members of the intermediate filament (IF) protein family. It has been claimed that mammalian cells contain either all three lamins or lamin B alone. Using monoclonal antibodies specific for B-type lamins and cDNA cloning we identified a second major mammalian B-type lamin (murine lamin B2), thus showing that lamin composition in mammals is more complex than previously thought. Lamin B2 is coexpressed with lamin B1 (formerly termed lamin B) in all somatic cells and mammalian species that we analysed, including a variety of cells currently believed to contain only a single lamin. This suggests that two B-type lamins are necessary to form a functional lamina in mammalian somatic cells. By cDNA cloning we found that Xenopus laevis lamin LII is the amphibian homolog of mammalian lamin B2. Lamin expression during embryogenesis of amphibians and mammals shows striking similarities. The first lamins expressed in the early embryo are the two B-type lamins, while A-type lamins are only detected much later in development. These findings indicate that the genomic differentiation into two B-type lamins occurred early in vertebrate evolution and has been maintained in both their primary structure and pattern of expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.