Trial reportAnnals of surgery1990
Addition of parenteral cefoxitin to regimen of oral antibiotics for elective colorectal operations. A randomized prospective study.
Trial report in Annals of surgery, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Mechanical bowel preparation and antibiotics in elective colorectal surgery: network meta-analysis.BJS open · 2023Pooled it
- Antibiotic prophylaxis in colorectal surgery: are oral, intravenous or both best and is mechanical bowel preparation necessary?Techniques in coloproctology · 2020Pooled it
- Antimicrobial prophylaxis for colorectal surgery.The Cochrane database of systematic reviews · 2014Pooled it
- Antimicrobial prophylaxis in colorectal surgery.Quality in health care : QHC · 1999Pooled it
- Right colon, left colon, and rectal surgeries are not similar for surgical site infection development. Analysis of 277 elective and urgent colorectal resections.International journal of colorectal disease · 2011Trial
- Selective decontamination of the colon before elective colorectal surgery. West of Scotland Surgical Infection Study Group.World journal of surgeryTrial
- Risk adjustment performance between NNIS index and NHSN model for postoperative colorectal surgical site infection: A retrospective cohort study.Annals of medicine and surgery (2012) · 2022Article
- Risk Factors for Wound Infection After Laparoscopic Surgery for Colon Cancer.Surgical laparoscopy, endoscopy & percutaneous techniques · 2020Article
- Infection control in colon surgery.Langenbeck's archives of surgery · 2016Review
- Risk factors for surgical site infection following colorectal resection: a multi-institutional study.International journal of colorectal disease · 2016Article
- Bowel Preparation before Elective Surgery.Clinics in colon and rectal surgery · 2013Review
- The prevention of surgical site infection in elective colon surgery.Scientifica · 2013Review
- A statewide assessment of surgical site infection following colectomy: the role of oral antibiotics.Annals of surgery · 2010Article
- Implementing a standard protocol to decrease the incidence of surgical site infections in rectal cancer surgery.Surgery today · 2010Article
- Risk factors for wound infection after surgery for colorectal cancer.World journal of surgery · 2008Article
- Wound infection after elective colorectal resection.Annals of surgery · 2004Article
- Risk factors for surgical site infection after elective resection of the colon and rectum: a single-center prospective study of 2,809 consecutive patients.Annals of surgery · 2001Article
- Addition of parenteral cefoxitin to regimen of oral antibiotics for elective colorectal operations.Annals of surgery · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of cefoxitin, a perioperative parenteral antibiotic, combined with mechanical bowel preparation and oral antibiotics to prevent wound infections and other septic complications in patients undergoing elective colorectal operations, was examined in a prospective randomized study. All 197 patients who completed the study received mechanical bowel preparation and oral neomycin/erythromycin base. In addition a perioperative parenteral antibiotic was given in three divided doses to 101 patients. The other 96 patients received no parenteral antibiotics. The overall incidence of intra-abdominal septic complications was 7.3% (7 of 96) in the control group (no cefoxitin) and 5% (5 of 101) in the treatment group (cefoxitin). This difference was not statistically significant. The incidence of abdominal wound infection was 14.6% in the control group and 5% in the treatment group, a statistically significant difference (p = 0.02). The addition of perioperative parenteral cefoxitin greatly reduced the incidence of wound infections in patients undergoing elective colorectal operations who had been prepared with mechanical bowel cleansing and oral antimicrobial agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.