ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2011
Feeding into old age: long-term effects of dietary fatty acid supplementation on tissue composition and life span in mice.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Mitochondrial membrane remodeling during heat acclimation in Mongolian gerbils.Marine life science & technology · 2025Article
- Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates.Animals : an open access journal from MDPI · 2024Review
- Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation.EBioMedicine · 2024Review
- Summer fades, deer change: Photoperiodic control of cellular seasonal acclimatization of skeletal muscle.iScience · 2024Article
- A Walnut Diet in Combination with Enriched Environment Improves Cognitive Function and Affects Lipid Metabolites in Brain and Liver of Aged NMRI Mice.Neuromolecular medicine · 2021Article
- n-3 polyunsaturated fatty acids as modulators of thermogenesis in Ames dwarf mice.GeroScience · 2020Article
- Challenging a "Cushy" Life: Potential Roles of Thermogenesis and Adipose Tissue Adaptations in Delayed Aging of Ames and Snell Dwarf Mice.Metabolites · 2020Review
- Sarcolemmal dependence of cardiac protection and stress-resistance: roles in aged or diseased hearts.British journal of pharmacology · 2016Review
- Fish oil supplements, longevity and aging.Aging · 2016Article
- DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid.Diabetology & metabolic syndrome · 2016Article
- The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Healthy n-6/n-3 fatty acid composition from five European game meat species remains after cooking.BMC research notes · 2015Article
- Target of rapamycin activation predicts lifespan in fruit flies.Cell cycle (Georgetown, Tex.) · 2015Article
- Article
- Making heads or tails of mitochondrial membranes in longevity and aging: a role for comparative studies.Longevity & healthspan · 2014Article
- Polyunsaturated fats, membrane lipids and animal longevity.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- Phospholipid composition and longevity: lessons from Ames dwarf mice.Age (Dordrecht, Netherlands) · 2013Article
- Article
- Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes.Nutrition & metabolism · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Smaller mammals, such as mice, possess tissues containing more polyunsaturated fatty acids (PUFAs) than larger mammals, while at the same time live shorter lives. These relationships have been combined in the 'membrane pacemaker hypothesis of aging'. It suggests that membrane PUFA content might determine an animal's life span. PUFAs in general and certain long-chain PUFAs in particular, are highly prone to lipid peroxidation which brings about a high rate of reactive oxygen species (ROS) production. We hypothesized that dietary supplementation of either n-3 or n-6 PUFAs might affect (1) membrane phospholipid composition of heart and liver tissues and (2) life span of the animals due to the altered membrane composition, and subsequent effects on lipid peroxidation. Therefore, we kept female laboratory mice from the C57BL/6 strain on three diets (n-3 PUFA rich, n-6 PUFA rich, control) and assessed body weights, life span, heart, and liver phospholipid composition after the animals had died. We found that while membrane phospholipid composition clearly differed between feeding groups, life span was not directly affected. However, we were able to observe a positive correlation between monounsaturated fatty acids in cardiac muscle and life span.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.