ArticleJournal of natural medicines2011
Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro.
Article in Journal of natural medicines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 74 citations in OpenAlex.
- The antibacterial effect of Tanacetum argyrophyllum essential oil on kanamycin-resistant Escherichia coli by disruption of energy metabolism and proton fluxes.Scientific reports · 2026Article
- Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome.Journal of natural medicines · 2024Article
- Review
- Essential Oil and Non-Volatile Metabolites fromPlants (Basel, Switzerland) · 2022Article
- Effect of Ylang-Ylang (Molecules (Basel, Switzerland) · 2022Article
- Review
- Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oils and Crude Extracts of Four CharacteristicPlants (Basel, Switzerland) · 2021Article
- Potential of Using Ginger Essential Oils-Based Nanotechnology to Control Tropical Plant Diseases.The plant pathology journal · 2020Review
- Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils.BMC complementary and alternative medicine · 2019Article
- Supercritical Fluid Extract ofInternational journal of molecular sciences · 2019Article
- Article
- Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy.Molecules (Basel, Switzerland) · 2017Review
- Anti-Inflammatory Effects of the Essential Oils of Ginger (PharmaNutrition · 2016Article
- Cytotoxicity Evaluation of Essential Oil and its Component from Zingiber officinale Roscoe.Toxicological research · 2016Article
- VOLATILE CONSTITUENTS OF GINGER OIL PREPARED ACCORDING TO IRANIAN TRADITIONAL MEDICINE AND CONVENTIONAL METHOD: A COMPARATIVE STUDY.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan.Journal of natural medicines · 2014Article
- Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.PloS one · 2014Article
- Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Obesity-related cardiovascular risk factors after long- term resistance training and ginger supplementation.Journal of sports science & medicine · 2011Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zingiber officinale Roscoe, popular name ginger, is grown naturally in many parts of the world, including Brazil. Ginger is used in pharmaceutical, cosmetic, and food and beverage industries and the essential oil has been used in folk medicine for manifold conditions including as an analgesic, anti-inflammatory, and antirheumatic. The purpose of this study was to investigate the effects of ginger (Zingiber officinale Roscoe) essential oil (GEO) in an in vitro chemotaxis assay and on leukocyte-endothelial interactions in vivo. GEO was analyzed by GC-MS and the main components identified were ar-curcumene (59%), β-myrcene (14%), 1,8-cineol (8%), citral (7.5%), and zingiberene (7.5%). Oral administration of GEO (200-500 mg/kg) reduced the rolling and leukocyte adherence after 2 h of carrageenan injection (100 μg) into the scrotal chamber. The number of leukocytes migrated to the perivascular tissue 4 h after the irritant stimulus was also diminished. GEO in all doses tested (10(-4), 10(-3), or 10(-2) μL/mL) caused a significant reduction of leukocyte chemotaxis (35.89 ± 4.33, 30.67 ± 0.70, and 35.85 ± 3.83%, respectively) toward casein stimuli. The data presented showed direct and systemic effects of GEO on leukocyte migration as an important mechanism of the anti-inflammatory action of ginger.
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