ArticleOral and maxillofacial surgery2012
Diffuse swelling of the buccal mucosa and palate as first and only manifestation of an extranodal non-Hodgkin 'double-hit' lymphoma: report of a case.
Article in Oral and maxillofacial surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 15 citations in OpenAlex.
- Uncommon presentation of diffuse large B-cell lymphoma: oral and pulmonary involvements in a young patient: a case report.Journal of medical case reports · 2024Article
- Orofacial symptoms suggestive of malignant lesions and the role of imaging: literature review and case presentation.Oral radiology · 2023Review
- Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review.BMC oral health · 2022Article
- HIV-Associated "Double-Hit" Lymphoma of the Tonsil: A First Reported Case.Head and neck pathology · 2020Article
- A case of systemic precursor T-cell lymphoblastic lymphoma presenting with single tooth mobility.SAGE open medical case reports · 2020Article
- Extranodal lymphoma arising within the maxillary alveolus: a systematic review.Oral radiology · 2018Article
- Primary diffuse large B-cell lymphoma in the anterior hard palate: A rare case report with review of literature.Journal of oral and maxillofacial pathology : JOMFP · 2014Article
- Non-Hodgkins lymphoma of maxilla: A rare entity.National journal of maxillofacial surgery · 2011Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMost of the lymphomas arising in the oral cavity are of B-cell origin. Among these, diffuse large B-cell lymphomas are the most common. Diffuse large B-cell lymphomas may exhibit more than one chromosomal rearrangement and are then referred to as 'double-hit' or 'triple-hit' lymphomas. CASE REPORT: We present a case of an intraoral 'double-hit' lymphoma in a 76-year-old male who had been referred by an oral surgeon in private practice. Intraoral examination exhibited a firm, exophytic lesion in the region of the right hard palate and buccal mucosa with extension to the soft palate. Radiographic examination exhibited a massive thickening of the right sinus membrane, and arrosion of the lateral and basal cortical sinus walls in the right maxilla. After diagnosis of the lesion, the patient was treated with six cycles of chemotherapy. DISCUSSION: Lymphomas arising within the oral cavity account for less than 5% of all oral malignancies and typically affect the palatine tonsils and the palate. 'Double-hit' lymphomas are associated with older age, usually present with an advanced stage of disease, and show an aggressive clinical behaviour. They normally have a poor prognosis, even when treated with intensive chemotherapy regimens. Nevertheless, in the case presented, the patient was free of symptoms 1 year after initial diagnosis.
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