ArticleInternational journal of hypertension2010
An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population.
Article in International journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.PloS one · 2011Pooled it
- Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?Ageing research reviews · 2020Review
- New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors.Scientific reports · 2016Article
- The power comparison of the haplotype-based collapsing tests and the variant-based collapsing tests for detecting rare variants in pedigrees.BMC genomics · 2014Article
- A hidden Markov model for haplotype inference for present-absent data of clustered genes using identified haplotypes and haplotype patterns.Frontiers in genetics · 2014Article
- Haplotype-based methods for detecting uncommon causal variants with common SNPs.Genetic epidemiology · 2012Article
- Multilocus family-based association analysis of seven candidate polymorphisms with essential hypertension in an african-derived semi-isolated brazilian population.International journal of hypertension · 2012Article
- A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies.Human heredity · 2011Article
- Lack of association between common endothelial nitric oxide synthase gene haplotypes and left ventricular hypertrophy in hypertension.DNA and cell biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was tested in a case-control sample of 230 patients with essential hypertension and 306 healthy controls. Haplotype analysis was also performed. The mutant allele a(∗) of the 4a/b polymorphism showed a protective effect against hypertension under a dominant model (odds ratio = 0.64, 95% confidence interval (0.44-0.93)), although this effect was not significant after the adjustment for covariates (P = 0.06). The estimated frequency of the haplotype composed of the T786(∗), 4a(∗), and G894(∗) alleles was significantly higher in controls (5.5%) compared to cases (2%). These results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.