ArticleInternational journal of hypertension2010
Roles of beta2- and beta3-adrenoceptor polymorphisms in hypertension and metabolic syndrome.
Article in International journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Onset Mechanisms and Prognosis of Neurally Mediated Syncope.Reports (MDPI) · 2023Review
- Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients.PloS one · 2021Article
- The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD).Molecular medicine (Cambridge, Mass.) · 2020Article
- Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents.Pediatric gastroenterology, hepatology & nutrition · 2019Article
- Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients.PloS one · 2019Article
- Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population.PloS one · 2019Article
- Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity.Nutrients · 2018Article
- ADRB3 polymorphism rs4994 (Trp64Arg) associates significantly with bodyweight elevation and dyslipidaemias in Saudis but not rs1801253 (Arg389Gly) polymorphism in ARDB1.Lipids in health and disease · 2018Article
- Posttraumatic stress disorder: A metabolic disorder in disguise?Experimental neurology · 2016Review
- β-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Children.Journal of clinical research in pediatric endocrinology · 2015Article
- The Trp64Arg β3-adrenergic receptor gene polymorphism is associated with endothelium-dependent vasodilatation.Journal of human hypertension · 2015Article
- Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues.Journal of translational medicine · 2015Article
- Hypertension and diabetes in obesity.International journal of hypertension · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension, diabetes mellitus (especially type 2 diabetes mellitus), metabolic syndrome and obesity are rapidly growing public health problems. Sympathetic nerve activation is observed in obesity, hypertension and diabetes mellitus, which have strong genetic as well as environmental determinants. Reduced energy expenditure and resting metabolic rate are predictive of weight gain, and the sympathetic nervous system participates in regulating energy balance through thermogenesis. The thermogenic effects of catecholamines in obesity have been mainly mediated via the β2- and β3-adrenergic receptors in humans. Further, β2-adrenoceptors importantly influence vascular reactivity and may regulate blood pressure. Genetic polymorphistns of the β-adrenoceptor gene have been shown to alter the function of several adrenoceptor subtypes and thus to modify the response to catecholamine. β2-adrenoceptor polymorphisms (Arg16Gly, Gln27Glu, and Thr164Ile) have been studied in relation to hypertension. Genetic variations in the β3-adrenoceptor (i.e. Try64Arg variant) are also associated with both obesity and hypertension. However, the precise relationships of the polymorphisms of β2- and β3-adrenoceptor genes with sympathetic nervous system activity, hypertension, and metabolic syndrome have not been fully clarified. This paper will discuss the current topics involving the influence of the sympathetic nervous system and β2- and β3- adrenoceptor polymorphisms in hypertension and metabolic syndrome.
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Registered trials
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