ArticleHuman genomics and proteomics : HGP2010
Gender dependence for a subset of the low-abundance signaling proteome in human platelets.
Article in Human genomics and proteomics : HGP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Sex dimorphisms in coagulation: Implications in trauma-induced coagulopathy and trauma resuscitation.American journal of hematology · 2024Review
- Lurbinectedin-induced thrombocytopenia: the role of body surface area.Cancer chemotherapy and pharmacology · 2022Article
- Circulating hsa-let-7e-5p and hsa-miR-125a-5p as Possible Biomarkers in the Diagnosis of Major Depression and Bipolar Disorders.Disease markers · 2022Article
- Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.Frontiers in endocrinology · 2021Article
- The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study.Journal of clinical medicine · 2019Article
- Sex Differences in Using Systemic Inflammatory Markers to Prognosticate Patients with Head and Neck Squamous Cell Carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- miRNA and mRNA expression analysis reveals potential sex-biased miRNA expression.Scientific reports · 2017Article
- Article
- Gender and anti-thrombotic therapy: from biology to clinical implications.Journal of cardiovascular translational research · 2014Review
- Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women.British journal of pharmacology · 2014Review
- Role of tumor suppressor p53 in megakaryopoiesis and platelet function.Experimental hematology · 2012Article
- Comparing the MicroRNA spectrum between serum and plasma.PloS one · 2012Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The incidence of cardiovascular diseases is ten-times higher in males than females, although the biological basis for this gender disparity is not known. However, based on the fact that antiplatelet drugs are the mainstay for prevention and therapy, we hypothesized that the signaling proteomes in platelets from normal male donors might be more activated than platelets from normal female donors. We report here that platelets from male donors express significantly higher levels of signaling cascade proteins than platelets from female donors. In silico connectivity analysis shows that the 24 major hubs in platelets from male donors focus on pathways associated with megakaryocytic expansion and platelet activation. By contrast, the 11 major hubs in platelets from female donors were found to be either negative or neutral for platelet-relevant processes. The difference may suggest a biological mechanism for gender discrimination in cardiovascular disease.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.