ArticleNature communications2010
G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion.
Article in Nature communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Mechanisms of Location Bias in G Protein-Coupled Receptors.Handbook of experimental pharmacology · 2026Review
- GPCRs identified on mitochondrial membranes: New therapeutic targets for diseases.Journal of pharmaceutical analysis · 2025Review
- Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors.Frontiers in immunology · 2025Review
- Engagement ofActa pharmaceutica Sinica. B · 2024Article
- Loss of cholinergic receptor muscarinic 1 impairs cortical mitochondrial structure and function: implications in Alzheimer's disease.Frontiers in cell and developmental biology · 2023Article
- Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer's disease.Frontiers in cell and developmental biology · 2023Article
- Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.Science (New York, N.Y.) · 2022Article
- Article
- G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer.British journal of cancer · 2021Article
- Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling.Cell systems · 2021Article
- Recent insights into the structure and function of Mitofusins in mitochondrial fusion.F1000Research · 2018Review
- Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.Cell death & disease · 2017Article
- Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!Cardiovascular drugs and therapy · 2017Review
- Article
- Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017Review
- Article
- GASZ and mitofusin-mediated mitochondrial functions are crucial for spermatogenesis.EMBO reports · 2016Article
- Zinc wave during the treatment of hypoxia is required for initial reactive oxygen species activation in mitochondria.International journal of physiology, pathophysiology and pharmacology · 2016Article
- Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.European journal of pharmacology · 2015Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitofusins (Mfns) mediate the fusion of mitochondrial membranes. However, little is known about how Mfns are regulated to control mitochondrial fusion, which is a multistep process requiring tethering and docking of the outer membranes of two mitochondria. In this study, we report that guanine nucleotide binding protein-β subunit 2 (Gβ2), a WD40 repeats protein and a member of the β-subunits of the heterotrimeric G proteins, has a crucial function in mitochondrial fusion. Gβ2 was found to be enriched on the surface of mitochondria and interacted with mitofusin 1 (Mfn1) specifically. Gβ2 also regulated the mobility of Mfn1 on the surface of the mitochondrial membrane and affected the mitochondrial fusion. Depletion of endogenous Gβ2 resulted in mitochondrial fragmentation, which could be rescued by exogenous Gβ2. These findings have thus uncovered a novel role of Gβ2 in regulating mitochondrial fusion through its interaction with Mfn1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.