ArticleMedicine and science in sports and exercise2011
Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue.
Article in Medicine and science in sports and exercise, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation withNutrients · 2026Review
- Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease.JCI insight · 2020Article
- Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase.Respiratory physiology & neurobiology · 2015Article
- Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species.Frontiers in physiology · 2015Review
- Diagnostic ultrasound imaging of mouse diaphragm function.Journal of visualized experiments : JoVE · 2014Article
- Diaphragm and ventilatory dysfunction during cancer cachexia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Cancer cachexia decreases specific force and accelerates fatigue in limb muscle.Biochemical and biophysical research communications · 2013Article
- Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledReactions involving thiol biochemistry seem to play a crucial role in skeletal muscle fatigue. N-acetylcysteine amide (NACA) and L-ergothioneine (ERGO) are thiol-based antioxidants available for human use that have not been evaluated for effects on muscle fatigue. PURPOSE: To test the hypothesis that NACA and ERGO delay skeletal muscle fatigue.
methodsWe exposed mouse diaphragm fiber bundles to buffer (CTRL), NACA, ERGO, or N-acetylcysteine (NAC; positive control). Treatments were performed in vitro using 10 mM for 60 min at 37 °C. After treatment, we determined the muscle force-frequency and fatigue characteristics.
resultsThe force-frequency relationship was shifted to the left by ERGO and to the right by NACA compared with CTRL and NAC. Maximal tetanic force was similar among groups. The total force-time integral (FTI; N · s · cm) during the fatigue trial was decreased by NACA (420 ± 35, P < 0.05), unaffected by ERGO (657 ± 53), and increased by NAC (P < 0.05) compared with CTRL (581 ± 54). The rate of contraction (dF/dtMAX) during the fatigue trial was not affected by any of the treatments tested. NAC, but not NACA or ERGO, delayed the slowing of muscle relaxation (dF/dtMIN) during fatigue.
conclusionsIn summary, NACA and ERGO did not delay skeletal muscle fatigue in vitro. We conclude that these antioxidants are unlikely to improve human exercise performance.
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