ArticleProceedings of the National Academy of Sciences of the United States of America2010
Pineal-specific agouti protein regulates teleost background adaptation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 74 citations in OpenAlex.
- Neural Melanocortin Receptors in Fish: Insights into Growth Regulation and Aquaculture Advancement.Biomolecules · 2026Review
- Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling.Frontiers in endocrinology · 2025Article
- Divergent Pharmacology and Biased Signaling of the Four Melanocortin-4 Receptor Isoforms in Rainbow Trout (Biomolecules · 2023Article
- Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain.The Journal of comparative neurology · 2023Article
- Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins inFrontiers in endocrinology · 2022Article
- Article
- Different Sources of Allelic Variation Drove Repeated Color Pattern Divergence in Cichlid Fishes.Molecular biology and evolution · 2021Article
- Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.PLoS genetics · 2020Article
- Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia.International journal of molecular sciences · 2020Article
- The genomics of coloration provides insights into adaptive evolution.Nature reviews. Genetics · 2020Review
- Developmental and Cellular Basis of Vertical Bar Color Patterns in the East African Cichlid FishFrontiers in cell and developmental biology · 2020Article
- HypothalamicFrontiers in physiology · 2020Article
- Evolutionary Dynamics of Structural Variation at a Key Locus for Color Pattern Diversification in Cichlid Fishes.Genome biology and evolution · 2019Article
- Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.Pigment cell & melanoma research · 2019Article
- Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System.Current biology : CB · 2019Article
- Analysis of the Role of the Mc4r System in Development, Growth, and Puberty of Medaka.Frontiers in endocrinology · 2019Article
- BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2017Article
- Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish.Scientific reports · 2017Article
- Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms.Current zoology · 2016Article
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11 authors at 5 institutions in 1 country.
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Abstract
Background adaptation is used by teleosts as one of a variety of camouflage mechanisms for avoidance of predation. Background adaptation is known to involve light sensing by the retina and subsequent regulation of melanophore dispersion or contraction in melanocytes, mediated by α-melanocyte-stimulating hormone and melanin-concentrating hormone, respectively. Here, we demonstrate that an agouti gene unique to teleosts, agrp2, is specifically expressed in the pineal and is required for up-regulation of hypothalamic pmch and pmchl mRNA and melanosome contraction in dermal melanocytes in response to a white background. floating head, a mutant with defective pineal development, exhibits defective up-regulation of mch mRNAs by white background, whereas nrc, a blind mutant, exhibits a normal response. These studies identify a role for the pineal in background adaptation in teleosts, a unique physiological function for the agouti family of proteins, and define a neuroendocrine axis by which environmental background regulates pigmentation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.