Evidence map›Paper›PMID 20980645›Full record

ArticleThe Journal of nutrition2010

Beta-carotene is an important vitamin A source for humans.

Tilman Grune, Georg Lietz, Andreu Palou, A Catharine Ross, Wilhelm Stahl, Guangweng Tang, David Thurnham, Shi-an Yin, Hans K Biesalski

3 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in The Journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 172 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01352975 completednot on this mapstarted 2011, after this paper: background citation

Longitudinal Investigation of Dark Adaptation in Participants With Age-Related Macular Degeneration

TypeobservationalSponsorNational Eye Institute (NEI)Ran2011Enrolled217ConditionsAge-Related Macular Degeneration
NCT02276014 nacompletednot on this mapstarted 2012, after this paper: background citation

Effect of SNPs in the Beta-carotene 15, 15'-Monooxygenase (BCMO1) Enzyme on Retinol Formation and Beta-carotene Plasma Responses

TypeinterventionalSponsorNewcastle-upon-Tyne Hospitals NHS TrustRan2012 to 2014Enrolled85ConditionsBeta-carotene Bioavailability, Vitamin A DeficiencyArmsBeta-carotene
NCT02373943 nacompletednot on this mapstarted 2015, after this paper: background citation

Bioavailability of Vitamin A From β-carotene-Biofortified Maize Porridge Consumed by Women and Men: Results of a Randomized Crossover Trial

TypeinterventionalSponsorInstitut de Recerca Biomèdica de LleidaRan2015 to 2016Enrolled20ConditionsHealthyArmsβ-carotene biofortified maize, β-carotene supplemented maize, Normal (non biofortified) maize without added β-carotene
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 5 syntheses or guidelines pooled it, 568 citations in OpenAlex.

  1. Pooled it
  2. Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2019
    Pooled it
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  13. Addition ofLife (Basel, Switzerland) · 2026
    Article
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 5 countries.

Tilman GruneInstitute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany.
Georg Lietz
Andreu Palou
A Catharine Ross
Wilhelm Stahl
Guangweng Tang
David Thurnham
Shi-an Yin
Hans K Biesalski
University of Hohenheim · DECentro de Investigación Biomédica en Red · ESChinese Center For Disease Control and Prevention · CNHeinrich Heine University Düsseldorf · DENewcastle University · GBPennsylvania State University · USTufts University · USUniversity of Ulster · GB

Funding

VITAMIN A NUTRITIONAL STATUS AND IMMUNE FUNCTIONR01DK041479 · NIDDK · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI ROSS, A. CATHARINE · 1989 to 2015
$4.0M
Molecular Regulation of LRAT and CYP26 in Lung and LiverR01CA090214 · NCI · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI ROSS, A. CATHARINE · 2001 to 2012
$2.6M
NCI NIH HHS R01 CA090214NIDDK NIH HHS R01 DK041479
6 · The paper itself

Abstract

Experts in the field of carotenoids met at the Hohenheim consensus conference in July 2009 to elucidate the current status of β-carotene research and to summarize the current knowledge with respect to the chemical properties, physiological function, and intake of β-carotene. The experts discussed 17 questions and reached an agreement formulated in a consensus answer in each case. These consensus answers are based on published valid data, which were carefully reviewed by the individual experts and are justified here by background statements. Ascertaining the impact of β-carotene on the total dietary intake of vitamin A is complicated, because the efficiency of conversion of β-carotene to retinol is not a single ratio and different conversion factors have been used in various surveys and following governmental recommendations within different countries. However, a role of β-carotene in fulfilling the recommended intake for vitamin A is apparent from a variety of studies. Thus, besides elucidating the various functions, distribution, and uptake of β-carotene, the consensus conference placed special emphasis on the provitamin A function of β-carotene and the role of β-carotene in the realization of the required/recommended total vitamin A intake in both developed and developing countries. There was consensus that β-carotene is a safe source of vitamin A and that the provitamin A function of β-carotene contributes to vitamin A intake.

Indexed as

beta CaroteneHumansVitamin Abeta CaroteneVitamin A

Identifiers

PMID20980645
PMCPMC3139236
OpenAlexW2144548956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.