ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Sodium/glucose cotransporter-1, sweet receptor, and disaccharidase expression in the intestine of the domestic dog and cat: two species of different dietary habit.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Macronutrient and energy metabolism changes in domestic cats when fed cornstarch, whey protein, and, poultry fat.The British journal of nutrition · 2026Article
- Carbohydrate source modulates protein and amino acid digestibility patterns in domestic cats.Frontiers in veterinary science · 2026Article
- Metabolic profiles show few differences in serum amino acid, one-carbon, and fatty acid compounds in dogs fed a plant-based ("vegan") or meat-based diet.Frontiers in veterinary science · 2025Article
- Determination of sweetener specificity of horse gut-expressed sweet taste receptor T1R2-T1R3 and its significance for energy provision and hydration.Frontiers in veterinary science · 2024Article
- The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut.Frontiers in cell and developmental biology · 2022Article
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Could Greater Time Spent Displaying Waking Inactivity in the Home Environment Be a Marker for a Depression-Like State in the Domestic Dog?Animals : an open access journal from MDPI · 2019Article
- Glucagon-Like Peptide-2 and the Enteric Nervous System Are Components of Cell-Cell Communication Pathway Regulating Intestinal NaFrontiers in nutrition · 2018Article
- Managing feline diabetes: current perspectives.Veterinary medicine (Auckland, N.Z.) · 2018Review
- Cats and Carbohydrates: The Carnivore Fantasy?Veterinary sciences · 2017Review
- Training the Gut for Athletes.Sports medicine (Auckland, N.Z.) · 2017Review
- Hypothalamic Integration of Metabolic, Endocrine, and Circadian Signals in Fish: Involvement in the Control of Food Intake.Frontiers in neuroscience · 2017Review
- New Approaches to Feline Diabetes Mellitus: Glucagon-like peptide-1 analogs.Journal of feline medicine and surgery · 2016Review
- What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters.Journal of veterinary internal medicine · 2016Review
- Sodium-glucose cotransport.Current opinion in nephrology and hypertension · 2015Review
- Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight.Chemosensory perception · 2015Article
- Article
- Evolution of glucose utilization: glucokinase and glucokinase regulator protein.Molecular phylogenetics and evolution · 2014Review
- Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores.Frontiers in endocrinology · 2013Review
- Comparative digestive physiology.Comprehensive Physiology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The domestic cat (Felis catus), a carnivore, naturally eats a very low carbohydrate diet. In contrast, the dog (Canis familiaris), a carno-omnivore, has a varied diet. This study was performed to determine the expression of the intestinal brush border membrane sodium/glucose cotransporter, SGLT1, sweet receptor, T1R2/T1R3, and disaccharidases in these species adapted to contrasting diets. The expression (this includes function) of SGLT1, sucrase, maltase and lactase were determined using purified brush border membrane vesicles and by quantitative immunohistochemistry of fixed tissues. The pattern of expression of subunits of the sweet receptor T1R2 and T1R3 was assessed using fluorescent immunohistochemistry. In proximal, middle, and distal small intestine, SGLT1 function in dogs was 1.9- to 2.3-fold higher than in cats (P = 0.037, P = 0.0011, P = 0.027, respectively), and SGLT1 protein abundance followed an identical pattern. Both cats and dogs express T1R3 in a subset of intestinal epithelial cells, and dogs, but not cats, express T1R2. In proximal and middle regions, there were 3.1- and 1.6-fold higher lactase (P = 0.006 and P = 0.019), 4.4- and 2.9-fold higher sucrase (both P < 0.0001), and 4.6- and 3.1-fold higher maltase activity (P = 0.0026 and P = 0.0005), respectively, in the intestine of dogs compared with cats. Dogs have a potential higher capacity to digest and absorb carbohydrates than cats. Cats may suffer from carbohydrate malabsorption following ingestion of high-carbohydrate meals. However, dogs have a digestive ability to cope with diets containing significant levels of carbohydrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.