ArticleMolecular biology of the cell2010
Zds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Substrate recognition principles for the PP2A-B55 protein phosphatase.Science advances · 2024Article
- Article
- PP2AJournal of cell science · 2020Article
- Cdc14 activation requires coordinated Cdk1-dependent phosphorylation of Net1 and PP2A-Cdc55 at anaphase onset.Cellular and molecular life sciences : CMLS · 2019Article
- Ser/Thr protein phosphatases in fungi: structure, regulation and function.Microbial cell (Graz, Austria) · 2019Review
- SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast.GigaScience · 2018Article
- Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.The Journal of biological chemistry · 2017Article
- Zds1/Zds2-PP2ACdc55 complex specifies signaling output from Rho1 GTPase.The Journal of cell biology · 2016Article
- Article
- Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.Cell cycle (Georgetown, Tex.) · 2014Article
- α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2014Article
- Cell cycle checkpoint regulators reach a zillion.Cell cycle (Georgetown, Tex.) · 2013Review
- Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment.Molecular and cellular biology · 2013Article
- Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.PLoS genetics · 2013Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.Current opinion in cell biology · 2012Review
- Zds1 regulates PP2A(Cdc55) activity and Cdc14 activation during mitotic exit through its Zds_C motif.Journal of cell science · 2012Article
- A link between mitotic entry and membrane growth suggests a novel model for cell size control.The Journal of cell biology · 2012Article
- Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast.The Journal of cell biology · 2011Article
- The Zds proteins control entry into mitosis and target protein phosphatase 2A to the Cdc25 phosphatase.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Deletion of the paralogs ZDS1 and ZDS2 in the budding yeast Saccharomyces cerevisiae causes a mis-regulation of polarized cell growth. Here we show a function for these genes as regulators of the Swe1p (Wee1p) kinase-dependent G2/M checkpoint. We identified a conserved domain in the C-terminus of Zds2p consisting of amino acids 813-912 (hereafter referred to as ZH4 for Zds homology 4) that is required for regulation of Swe1p-dependent polarized bud growth. ZH4 is shown by protein affinity assays to be necessary and sufficient for interaction with Cdc55p, a regulatory subunit of protein phosphatase 2A (PP2A). We hypothesized that the Zds proteins are in a pathway that negatively regulates the Swe1p-dependent G2/M checkpoint via Cdc55p. Supporting this model, deletion of CDC55 rescues the aberrant bud morphology of a zds1Δzds2Δ strain. We also show that expression of ZDS1 or ZDS2 from a strong galactose-inducible promoter can induce mitosis even when the Swe1p-dependent G2/M checkpoint is activated by mis-organization of the actin cytoskeleton. This negative regulation requires the CDC55 gene. Together these data indicate that the Cdc55p/Zds2p module has a function in the regulation of the Swe1p-dependent G2/M checkpoint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.