ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Comparison Between Viscous Teardrops and Saline Solution to Fill Orthokeratology Contact Lenses Before Overnight Wear.Eye & contact lens · 2018Trial
- Plasma metabolomic signatures of migraine in 479,760 adults.iScience · 2026Article
- Beyond symptom: Exploring the analgesic properties of vomiting in patients with migraine.Headache · 2026Article
- Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine.The journal of headache and pain · 2026Article
- Plasma proteomics identifies proteins and pathways associated with incident migraine in 50,668 adults.The journal of headache and pain · 2026Article
- Somatosensory cortical progesterone receptor signaling regulates the episodic to chronic migraine transformation.Neurobiology of disease · 2026Article
- Is canonical SD a clinically relevant model of migraine? Argument con.The journal of headache and pain · 2025Review
- Article
- Unraveling the interplay of neuroinflammatory signaling between parenchymal and meningeal cells in migraine headache.The journal of headache and pain · 2024Review
- Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.The journal of headache and pain · 2024Review
- Identification of brain areas in mice with peak neural activity across the acute and persistent phases of post-traumatic headache.Cephalalgia : an international journal of headache · 2023Article
- Central generators of migraine and autonomic cephalalgias as targets for personalized pain management: Translational links.European journal of pain (London, England) · 2023Review
- Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping.Molecular brain · 2022Article
- KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HTCephalalgia : an international journal of headache · 2022Article
- Altered Cortical Trigeminal Fields Excitability by Spreading Depolarization Revealed withThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Should "Retro-ocular Pain, Photophobia and Visual Acuity Loss" Be Recognised as a Distinct Entity? The ROPPVAL Syndrome.Neuro-ophthalmology (Aeolus Press) · 2021Article
- Connections between intrinsically photosensitive retinal ganglion cells and TBI symptoms.Neurology · 2020Review
- Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Multisensory Sensitivity is Related to Deep-Tissue but Not Cutaneous Pain Sensitivity in Healthy Individuals.Journal of pain research · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in cortical excitability are implicated in the pathophysiology of migraine. However, the relationship between cortical spreading depression (CSD) and headache has not been fully elucidated. We aimed to identify the corticofugal networks that directly influence meningeal nociception in the brainstem trigeminocervical complex (Sp5C) of the rat. Cortical areas projecting to the brainstem were first identified by retrograde tracing from Sp5C areas that receive direct meningeal inputs. Anterograde tracers were then injected into these cortical areas to determine the precise pattern of descending axonal terminal fields in the Sp5C. Descending cortical projections to brainstem areas innervated by the ophthalmic branch of the trigeminal nerve originate contralaterally from insular (Ins) and primary somatosensory (S1) cortices and terminate in laminae I-II and III-V of the Sp5C, respectively. In another set of experiments, electrophysiological recordings were simultaneously performed in Ins, S1 or primary visual cortex (V1), and Sp5C neurons. KCl was microinjected into such cortical areas to test the effects of CSD on meningeal nociception. CSD initiated in Ins and S1 induced facilitation and inhibition of meningeal-evoked responses, respectively. CSD triggered in V1 affects differently Ins and S1 cortices, enhancing or inhibiting meningeal-evoked responses of Sp5C, without affecting cutaneous-evoked nociceptive responses. Our data suggest that "top-down" influences from lateralized areas within Ins and S1 selectively affect interoceptive (meningeal) over exteroceptive (cutaneous) nociceptive inputs onto Sp5C. Such corticofugal influences could contribute to the development of migraine pain in terms of both topographic localization and pain tuning during an attack.
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