ArticleJournal of clinical microbiology2011
Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Cryptococcosis-a systematic review to inform the World Health Organization Fungal Priority Pathogens List.Medical mycology · 2024Pooled it
- Neurological Sequelae After Paediatric Cryptococcal Meningitis.Journal of fungi (Basel, Switzerland) · 2025Review
- Genotyping Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- Review
- Fungal CNS Infections in Africa: The Neuroimmunology of Cryptococcal Meningitis.Frontiers in immunology · 2022Review
- Genotype, Antifungal Susceptibility, and Virulence of Clinical South AfricanJournal of fungi (Basel, Switzerland) · 2021Article
- Associations betweenJournal of fungi (Basel, Switzerland) · 2021Review
- Review
- Article
- Mortality due to Cryptococcus neoformans and Cryptococcus gattii in low-income settings: an autopsy study.Scientific reports · 2019Observational
- Article
- Clinical characteristics and prognosis of pediatric cryptococcosis in Beijing Children's Hospital, 2002-2014.European journal of pediatrics · 2017Article
- MLST-Based Population Genetic Analysis in a Global Context Reveals Clonality amongst Cryptococcus neoformans var. grubii VNI Isolates from HIV Patients in Southeastern Brazil.PLoS neglected tropical diseases · 2017Article
- Cryptococcal Disease in HIV-Infected Children.Current infectious disease reports · 2016Review
- Cryptococcal Meningitis Presenting as a Complication in HIV-infected Children: A Case Series From Sub-Saharan Africa.The Pediatric infectious disease journal · 2016Article
- Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana.Molecular ecology · 2015Article
- Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia.The Pediatric infectious disease journal · 2015Article
- Molecular typing of clinical Cryptococcus neoformans isolates collected in Germany from 2004 to 2010.Medical microbiology and immunology · 2014Article
- Cryptococcosis in Colombian children and literature review.Memorias do Instituto Oswaldo Cruz · 2014Observational
- Multilocus sequence typing of serially collected isolates of Cryptococcus from HIV-infected patients in South Africa.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological basis for this age-related difference in the incidence of cryptococcosis, we investigated isolates of C. neoformans recovered from pediatric and adult patients during a 2-year period in South Africa. From reports to the Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA), we reviewed all cases of cryptococcosis in 2005 and 2006. We analyzed one isolate of C. neoformans from each of 82 pediatric patients (<15 years of age) and determined the multilocus sequence type (ST), mating type, ploidy, and allelic profile. This sample included isolates of all three molecular types of serotype A or C. neoformans var. grubii (molecular types VNI, VNII, and VNB) and one AD hybrid. Seventy-seven (94%) of the strains possessed the MATα mating type allele, and five were MATa. Seventy-five (91%) were haploid, and seven were diploid. A total of 24 different STs were identified. The ratios of each mating type and the proportion of haploids were comparable to those for the isolates that were obtained from 86 adult patients during the same period. Notably, the most prevalent pediatric ST was significantly associated with male patients. Overall, these pediatric isolates exhibited high genotypic diversity. They included a relatively large percentage of diploids and the rarely reported MATa mating type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.