Evidence map›Paper›PMID 20980485›Full record

Trial reportThe American journal of clinical nutrition2011

Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study.

Elizabeth T Jacobs, Cynthia A Thomson, Shirley W Flatt, Wael K Al-Delaimy, Elizabeth A Hibler, Lovell A Jones, Elizabeth C Leroy, Vicky A Newman, Barbara A Parker, Cheryl L Rock and 1 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00003787 (Dietary Intervention in Women Who Have Been Treated For Stage I, Stage II, or Stage III Breast Cancer), which is not on this map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00003787 completednot on this map

Dietary Intervention in Women Who Have Been Treated For Stage I, Stage II, or Stage III Breast Cancer: Women's Healthy Eating and Living (WHEL) Study

TypeobservationalSponsorUniversity of California, San DiegoRan1995 to 2018Enrolled3,088ConditionsBreast CancerArmseducational/counseling intervention, therapeutic dietary intervention
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Vitamin D supplementation for prevention of cancer in adults.The Cochrane database of systematic reviews · 2014
    Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Lifestyle modifications for patients with breast cancer to improve prognosis and optimize overall health.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizabeth T JacobsArizona Cancer Center, University of Arizona, Tucson AZ, USA. jacobse@u.arizona.edu
Cynthia A Thomson
Shirley W Flatt
Wael K Al-Delaimy
Elizabeth A Hibler
Lovell A Jones
Elizabeth C Leroy
Vicky A Newman
Barbara A Parker
Cheryl L Rock
John P Pierce

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAAS, RICHARD H · 1985 to 2010
$74.3M
XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI PARSONNET, JULIE · 1985 to 2008
$32.4M
ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
RCT OF PLANT-BASED DIET IN BREAST CANCER RECURRENCER01CA069375 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, JOHN P · 1998 to 2007
$25.5M
Cancer Prevention and Control Translational ResearchR25CA078447 · NCI · UNIVERSITY OF ARIZONA · PI ALBERTS, DAVID SAMUEL · 1998 to 2014
$7.6M
VDR Variants, Nutrient Intakes, and Adenoma RecurrenceK07CA106269 · NCI · UNIVERSITY OF ARIZONA · PI JACOBS, ELIZABETH T · 2005 to 2009
$665k
Serum 25(OH)D, Vitamin D Intake, and Breast Cancer Recurrence in the WHEL StudyR01CA134460 · NCI · UNIVERSITY OF ARIZONA · PI JACOBS, ELIZABETH T · 2008 to 2010
$634k
NCI NIH HHS CA69375NCI NIH HHS K07 CA106269NCI NIH HHS K07CA106269NCI NIH HHS R01 CA069375NCI NIH HHS R01 CA134460NCI NIH HHS R01CA134460NCI NIH HHS R25 CA078447NCRR NIH HHS M01 RR000070NCRR NIH HHS M01 RR000079NCRR NIH HHS M01-RR00070NCRR NIH HHS M01-RR00079NCRR NIH HHS M01 RR000827NCRR NIH HHS M01-RR00827
6 · The paper itself

Abstract

backgroundThere is a paucity of research evaluating the relation between vitamin D and recurrence of breast cancer after treatment.

objectiveThis study was designed to evaluate the associations between circulating concentrations of 25-hydroxyvitamin D [25(OH)D] and dietary, supplemental, and total intake of vitamin D and recurrent or new breast cancer events within the Women's Healthy Eating and Living (WHEL) Study.

designA prospective cohort study design (n = 3085) was used to evaluate the relation between dietary, supplemental, and total vitamin D intake and recurrent breast cancer, and a nested case-control study with 512 matched pairs was used for analysis of the association between 25(OH)D and breast cancer recurrence.

resultsNo relation between 25(OH)D and breast cancer recurrence was observed. Compared with women with serum concentrations of 25(OH)D ≥ 30 ng/mL, adjusted odds ratios (95% CI) for breast cancer recurrence were 1.14 (0.57, 2.31) for those with concentrations < 10 ng/mL, 1.00 (0.68-1.48) for concentrations ≥ 10 and < 20 ng/mL, and 1.05 (0.76, 1.47) for concentrations ≥ 20 and < 30 ng/mL. No significant associations were observed when analyses were stratified by pre- and postmenopausal status or for local, regional, or distant recurrence or death. Vitamin D intake was not related to breast cancer recurrence overall, although for premenopausal women there was a significant inverse association between dietary vitamin D intake and recurrence (P for trend = 0.02).

conclusionThese results do not provide support for a relation between concentrations of 25(OH)D after treatment and the recurrence of breast cancer. This trial is registered at clinicaltrials.gov for the WHEL Study as NCT00003787.

Indexed as

Breast NeoplasmsCohort StudiesDietary SupplementsFemaleHumansNeoplasm Recurrence, LocalProspective StudiesVitamin DWomen's Health25-hydroxyvitamin DVitamin D

Identifiers

PMID20980485
PMCPMC3001601

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.