ArticleAmerican journal of physiology. Renal physiology2011
Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK-Mediated Autophagy.Aging cell · 2025Article
- Efficient and selective kidney targeting by chemically modified carbohydrate conjugates.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Emerging roles of proximal tubular endocytosis in renal fibrosis.Frontiers in cell and developmental biology · 2023Review
- Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease.Progress in retinal and eye research · 2022Review
- The sugar daddy: the role of the renal proximal tubule in glucose homeostasis.American journal of physiology. Cell physiology · 2022Review
- Pacsin2 is required for endocytosis in the zebrafish pronephric tubule.Biology open · 2022Article
- Endocytic adaptation to functional demand by the kidney proximal tubule.The Journal of physiology · 2021Article
- Transcriptional Programs Driving Shear Stress-Induced Differentiation of Kidney Proximal Tubule Cells in Culture.Frontiers in physiology · 2020Article
- Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.BMC nephrology · 2017Article
- Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway.Molecular biology of the cell · 2017Article
- Receptor-Mediated Endocytosis in the Proximal Tubule.Annual review of physiology · 2017Review
- Article
- Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia.PloS one · 2016Article
- Sodium-glucose cotransport.Current opinion in nephrology and hypertension · 2015Review
- Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney.American journal of physiology. Renal physiology · 2014Article
- Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts.Developmental biology · 2014Article
- Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Imaging the dynamics of endocytosis in live mammalian tissues.Cold Spring Harbor perspectives in biology · 2014Review
- Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone resistance owing to heterozygous Gαs disruption.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.American journal of physiology. Renal physiology · 2013Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Kidney proximal tubule (PT) cells are specialized for the uptake and transport of ions, solutes, peptides, and proteins. These functions are often regulated by hormones that signal at the cell surface and are internalized by clathrin-mediated endocytosis. However, the caveolin/caveolae pathway has also been implicated in normal PT function, often based on data from isolated PTs or PT cells in culture. Although we reported previously that caveolae and caveolin 1 are not detectable in PTs in vivo, reports of caveolin expression and function in PT cells appear periodically in the literature. Therefore, we reexamined caveolin expression in PTs in vivo, in isolated "purified" PTs following collagenase digestion, and in cultured PT cells. Caveolin 1 and 2 protein, mRNA, or immunofluorescence was undetectable in PTs in vivo, but PT cell cultures expressed caveolin 1 and/or 2. Furthermore, caveolin 1 and 2 mRNAs were detected in isolated PTs along with the endothelial markers CD31 and ICAM1. In contrast, no caveolin or endothelial marker mRNAs were detectable in samples isolated from snap-frozen kidneys by laser cut microdissection, which eliminates contamination by other cell types. We conclude 1) caveolin 1 and 2 are not normally expressed by PT cells in situ, 2) caveolin expression is "activated" in cultured PT cells, 3) contamination with non-PT, caveolin-expressing cells is a potential source of caveolin 1 and 2 that must be taken into account when isolated PTs are used in studies to correlate expression of these proteins with PT function.
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