ArticleMutagenesis2011
Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay.
Article in Mutagenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Key Challenges forAlternatives to laboratory animals : ATLA · 2024Review
- Comparative potency analysis of whole smoke solutions in the bacterial reverse mutation test.Mutagenesis · 2021Article
- Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y TkMethods in molecular biology (Clifton, N.J.) · 2020Article
- Quantitative differentiation of whole smoke solution-induced mutagenicity in the mouse lymphoma assay.Environmental and molecular mutagenesis · 2018Article
- Review
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay.Mutagenesis · 2016Article
- Exposure of Human Lung Cells to Tobacco Smoke Condensate Inhibits the Nucleotide Excision Repair Pathway.PloS one · 2016Article
- Comparative evaluation of the mutagenicity and genotoxicity of smoke condensate derived from Korean cigarettes.Environmental health and toxicology · 2015Article
- Article
- Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Article
- Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells.Toxicology in vitro : an international journal published in association with BIBRA · 2013Article
- Genomic impact of cigarette smoke, with application to three smoking-related diseases.Critical reviews in toxicology · 2012Review
- Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells.Environmental and molecular mutagenesis · 2012Article
- Genetic toxicology and toxicogenomic analysis of three cigarette smoke condensates in vitro reveals few differences among full-flavor, blonde, and light products.Environmental and molecular mutagenesis · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cigarette smoke condensate (CSC) is genotoxic in nearly all assays in which it has been tested. In this study, we investigated the mutagenicity of 11 CSCs using the microwell and soft-agar versions of the mouse lymphoma assay (MLA). These CSCs were prepared from commercial or experimental cigarettes, 10 of them were produced using International Organisation for Standardisation (ISO) conditions and one CSC was generated using intense Massachusetts Department of Public Health (MDPH) conditions. In the presence of rat liver S9, the L5178Y/Tk(+/-) mouse lymphoma cells were treated with 11 CSCs at different concentrations (25-200 μg/ml) for 4 h. All CSCs resulted in dose-dependent increases of both cytotoxicity and mutagenicity in both versions of the MLA. The mutagenic potencies of the CSCs were calculated as mutant frequency per microgram CSC from the slope of the linear regression of the dose-response curves and showed no correlations with the tar yield of the cigarette or nicotine concentrations of the CSCs. Comparing two CSCs produced from the same commercial cigarettes using two different smoking conditions, the one generated under ISO conditions was more mutagenic than the other generated under intense conditions on a per microgram CSC basis. We also examined the loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 for the mutants induced by 11 CSCs. The most common type of mutation observed was LOH with chromosome damage spanning less than ∼34 Mbp. These results indicate that the MLA identifies different genotoxic potencies among a variety of CSCs and that the results from both versions of the assay are comparable.
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Registered trials
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