ArticleThe Journal of biological chemistry2011
Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies.International journal of biological sciences · 2026Review
- Malonate promotes CD8Cellular & molecular immunology · 2025Article
- Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity.Communications biology · 2024Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- Article
- Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.Cell reports · 2022Article
- Article
- IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection.Frontiers in immunology · 2019Article
- A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation.Immunity · 2016Article
- Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases.Journal of translational medicine · 2015Review
- Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Wnt your brain be inflamed? Yes, it Wnt!Trends in molecular medicine · 2013Review
- STAT6-dependent and -independent mechanisms in Th2 polarization.European journal of immunology · 2012Review
- Dendritic cells activated by IFN-γ/STAT1 express IL-31 receptor and release proinflammatory mediators upon IL-31 treatment.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The effects of TLR activation on T-cell development and differentiation.Clinical & developmental immunology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The Wnt pathway transcription factor T cell factor 1 (TCF-1) plays essential roles in the control of several developmental processes, including T cell development in the thymus. Although previously regarded as being required only during early T cell development, recent studies demonstrate an important role for TCF-1 in T helper 2 (Th2) cell polarization. TCF-1 was shown to activate expression of the Th2 transcription factor GATA-binding protein 3 (GATA3) and thus to promote the development of IL-4-producing Th2 cells independent of STAT6 signaling. In this study, we show that TCF-1 is down-regulated in human naive CD4(+) T cells cultured under Th2-polarizing conditions. The down-regulation is largely due to the polarizing cytokine IL-4 because IL-4 alone is sufficient to substantially inhibit TCF-1 expression. The IL-4-induced suppression of TCF-1 is mediated by STAT6, as shown by electrophoretic mobility shift assays, chromatin immunoprecipitation, and STAT6 knockdown experiments. Moreover, we found that IL-4/STAT6 predominantly inhibits the shorter, dominant-negative TCF-1 isoforms, which were reported to inhibit IL-4 transcription. Thus, this study provides a model for an IL-4/STAT6-dependent fine tuning mechanism of TCF-1-driven T helper cell polarization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.