SynthesisEuropean journal of pediatrics2011
Increased intima-media thickness of the carotid artery in childhood: a systematic review of observational studies.
Synthesis in European journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Premature subclinical atherosclerosis in children and young adults with juvenile idiopathic arthritis. A review considering preventive measures.Pediatric rheumatology online journal · 2016Pooled it
- Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.Pediatric diabetes · 2015 · on this mapTrial
- Carotid intima-media thickness and endothelial function in adolescents exposed to alcohol consumption and cigarette smoking in utero: a mediation analysis.BMC cardiovascular disorders · 2025Article
- Correlates of Hypertensive-Level BP in African American Adolescents.Journal of racial and ethnic health disparities · 2023Article
- Glycated Hemoglobin is a Significant Predictor of Femoral, but Not of Carotid or Popliteal, Intima-Media Thickness in Adolescents with Type 1 Diabetes: A Case-Series Study.Pediatric diabetes · 2023Article
- Serum amyloid A in children and adolescents: association with overweight and carotid intima-media thickness.Einstein (Sao Paulo, Brazil) · 2023Article
- Vascular Alterations Preceding Arterial Wall Thickening in Overweight and Obese Children.Journal of clinical medicine · 2022Article
- The Assessment of Maternal and Fetal Intima-Media Thickness in Perinatology.Journal of clinical medicine · 2022Review
- Obesity in adolescents associated with vascular aging - a study using ultra-high-resolution ultrasound.Upsala journal of medical sciences · 2022Article
- Pentraxin 3 as a Marker for Cardiovascular Disease Risk in Overweight and Obese Children.Acta Cardiologica Sinica · 2021Article
- Comparison of China Reference with Different National and International References: The Prevalence of High Blood Pressure in 695,302 Children and Adolescents in a Metropolis of Yangtze River Delta, China.International journal of hypertension · 2021Article
- Pediatric Hypertension: Parent Perspectives.Global pediatric health · 2020Article
- Article
- A Comparison of Metabolic Outcomes Between Obese HIV-Exposed Uninfected Youth From the PHACS SMARTT Study and HIV-Unexposed Youth From the NHANES Study in the United States.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Is atopic sensitization associated with indicators of early vascular ageing in adolescents?PloS one · 2019Article
- Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in young patients with congenital generalized lipodystrophy.Diabetology & metabolic syndrome · 2019Article
- INTIMA-MEDIA THICKNESS OF THE CAROTID ARTERIES IS AFFECTED BY PUBERTAL MATURATION IN HEALTHY ADOLESCENTS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2019Article
- Metabolically healthy and metabolically unhealthy obese children both have increased carotid intima-media thickness: a case control study.BMC cardiovascular disorders · 2018Article
- Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?European journal of pediatrics · 2018Article
- Undertreatment of hypertension and hypercholesterolaemia in children and adolescents with type 1 diabetes: long-term follow-up on time trends in the occurrence of cardiovascular disease, risk factors and medications use.British journal of clinical pharmacology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIncreased carotid intima-media thickness (cIMT) in adults may be caused by a childhood exposure to cardiovascular risk factors. We systematically reviewed observational studies to determine whether obesity, insulin-dependent diabetes mellitus (IDDM), dyslipidemia (DL), hypertension (HT), and chronic renal failure (CRF) are associated with increased cIMT in children and adolescent patients compared with control subjects. We performed a PubMed literature search from January 1986 to February 2010. Two reviewers separately verified the inclusion criteria of relevant studies for the objective of the review. The data extracted in the patient and control groups were sample size, age, gender, cIMT measurement methods, cIMT values, and statistical analysis results. From 348 citations, 65 cross-sectional studies (2 cited twice) with case-control design met the inclusion criteria: 26 in obesity, 14 in IDDM, 11 in DL, 8 in HT, and 8 in CRF. cIMT measurement protocols varied according to the studies, with measurements being performed on the common carotid artery in 65/67 cases and on the far wall in 57/67 cases. From the 67 studies cited, 22/26 reported a significantly increased cIMT in obese children and adolescents compared with the control group, 8/14 in IDDM patients, 10/11 in DL patients, 7/8 in HT patients, and 8/8 in CRF patients.
conclusionDespite the heterogeneity of ultrasound measurement methods, cIMT was significantly increased in 55 out of the 67 cited studies, confirming early vascular damages in pediatric populations with an increased future risk for vascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.