ArticlePflugers Archiv : European journal of physiology2011
Hypothyroidism of gene-targeted mice lacking Kcnq1.
Article in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of KvLQT1 potassium channel modulation on alveolar fluid homeostasis in an animal model of thiourea-induced lung edema.Frontiers in physiology · 2022Article
- Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type KInternational journal of molecular sciences · 2021Article
- Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation.Science advances · 2018Article
- Chansporter complexes in cell signaling.FEBS letters · 2017Review
- An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.Frontiers in pharmacology · 2017Article
- The Na+/I- symporter (NIS): mechanism and medical impact.Endocrine reviews · 2014Review
- Iodide transport: implications for health and disease.International journal of pediatric endocrinology · 2014Article
- A genome-wide association study of the human metabolome in a community-based cohort.Cell metabolism · 2013Article
- The KCNQ1-KCNE2 K⁺ channel is required for adequate thyroid I⁻ uptake.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch.PloS one · 2012Article
- The KCNE Tango - How KCNE1 Interacts with Kv7.1.Frontiers in pharmacology · 2012Article
- The role of imprinted genes in fetal growth abnormalities.Birth defects research. Part A, Clinical and molecular teratology · 2011Review
- KCNE2 and the K (+) channel: the tail wagging the dog.Channels (Austin, Tex.)Review
- Ion channel-transporter interactions.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Thyroid hormones T3/T4 participate in the fine tuning of development and performance. The formation of thyroid hormones requires the accumulation of I(-) by the electrogenic Na(+)/I(-) symporter, which depends on the electrochemical gradient across the cell membrane and thus on K(+) channel activity. The present paper explored whether Kcnq1, a widely expressed voltage-gated K(+) channel, participates in the regulation of thyroid function. To this end, Kcnq1 expression was determined by RT-PCR, confocal microscopy, and thyroid function analyzed in Kcnq1 deficient mice (Kcnq1 ( -/- )) and their wild-type littermates (Kcnq1 ( +/+ )). Moreover, Kcnq1 abundance and current were determined in the thyroid FRTL-5 cell line. Furthermore, mRNA encoding KCNQ1 and the subunits KCNE1-5 were discovered in human thyroid tissue. According to patch-clamp TSH (10 mUnits/ml) induced a voltage-gated K(+) current in FRTL-5 cells, which was inhibited by the Kcnq inhibitor chromanol (10 μM). Despite a tendency of TSH plasma concentrations to be higher in Kcnq1 ( -/- ) than in Kcnq1 ( +/+ ) mice, the T3 and T4 plasma concentrations were significantly smaller in Kcnq1 ( -/- ) than in Kcnq1 ( +/+ ) mice. Moreover, body temperature was significantly lower in Kcnq1 ( -/- ) than in Kcnq1 ( +/+ ) mice. In conclusion, Kcnq1 is required for proper function of thyroid glands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.