Clinical utility gene card for: hypophosphatasia.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Asfotase Alfa Treatment Improves Survival for Perinatal and Infantile Hypophosphatasia.The Journal of clinical endocrinology and metabolism · 2016
   Trial
2. Hypophosphatasia: 90 Years from a Canadian Discovery-A Comprehensive Review of theGenes · 2025
   Review
3. Dental manifestations of hypophosphatasia: translational and clinical advances.JBMR plus · 2025
   Review
4. Different Dental Manifestations in Sisters with the SameChildren (Basel, Switzerland) · 2022
   Article
5. Hypophosphatasia in adolescents and adults: overview of diagnosis and treatment.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
   Review
6. Loss-of-Function Mutations in the ALPL Gene Presenting with Adult Onset Osteoporosis and Low Serum Concentrations of Total Alkaline Phosphatase.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
   Article
7. Genetic analysis of adults heterozygous for ALPL mutations.Journal of bone and mineral metabolism · 2018
   Article
8. Hypophosphatasia: an overview of the disease and its treatment.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
   Review
9. Acute hypophosphatasemia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
   Article
10. Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

5 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as