ArticleHeredity2011
A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.
Article in Heredity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Genome-wide association analyses for meat quality traits in Chinese Erhualian pigs and a Western Duroc × (Landrace × Yorkshire) commercial population.Genetics, selection, evolution : GSE · 2015Pooled it
- Genomic insights into population structure, genetic diversity, and key traits of Jiangxi indigenous pigs.BMC genomics · 2025Article
- Article
- Discovery of Potential Candidate Genes for Coat Colour in Wuzhishan Pigs by Integrating SNPs and mRNA Expression Analysis.Animals : an open access journal from MDPI · 2024Article
- PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickens.Communications biology · 2024Article
- Genetic Structure and Genome-Wide Association Analysis of Growth and Reproductive Traits in Fengjing Pigs.Animals : an open access journal from MDPI · 2024Article
- Identification of Differentially Expressed Genes and microRNAs in the Gray and White Feather Follicles of Shitou Geese.Animals : an open access journal from MDPI · 2024Article
- Genetic variants in melanogenesis proteins TYRP1 and TYR are associated with the golden rhesus macaque phenotype.G3 (Bethesda, Md.) · 2023Article
- Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins.Communications biology · 2023Article
- Allelic to genome wide perspectives of swine genetic variation to litter size and its component traits.Molecular biology reports · 2023Review
- Identify known and novel candidate genes associated with backfat thickness in Duroc pigs by large-scale genome-wide association analysis.Journal of animal science · 2022Article
- A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius).PloS one · 2022Article
- Article
- Article
- Micro RNAs upregulated in Vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes cross-talk.Scientific reports · 2019Article
- Article
- Whole-Genome Resequencing IdentifiesFrontiers in genetics · 2019Article
- Comparative Transcriptome Analysis of Mink (Neovison vison) Skin Reveals the Key Genes Involved in the Melanogenesis of Black and White Coat Colour.Scientific reports · 2017Article
- Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene.Asian-Australasian journal of animal sciences · 2017Article
- Transcriptome analysis revealed chimeric RNAs, single nucleotide polymorphisms and allele-specific expression in porcine prenatal skeletal muscle.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown coat colour has been described in Chinese-Tibetan, Kele, and Dahe pigs. Here, we report the identification of a causal mutation underlying the brown colouration. We performed a genome-wide association study (GWAS) on Tibetan and Kele pigs, and found that brown colours in Chinese breeds are controlled by a single locus on pig chromosome 1. By using a haplotype-sharing analysis, we refined the critical region to a 1.5-Mb interval that encompasses only one pigmentation gene: tyrosinase-related protein 1 (TYRP1). Mutation screens of sequence variants in the coding region of TYRP1 revealed a strong candidate causative mutation (c.1484_1489del). The protein-altering deletion showed complete association with the brown colouration across Chinese-Tibetan, Kele, and Dahe breeds by occurring exclusively in brown pigs (n=121) and lacking in all non-brown-coated pigs (n=745) from 27 different breeds. The findings provide the compelling evidence that brown colours in Chinese indigenous pigs are caused by the same ancestral mutation in TYRP1. To our knowledge, this study gives the first description of GWAS identifying causal mutation for a monogenic trait in the domestic pig.
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