ArticleAmerican journal of physiology. Endocrinology and metabolism2011
Enteral arginase II provides ornithine for citrulline synthesis.
Article in American journal of physiology. Endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization.Nature communications · 2026Article
- A regulator of amino acid catabolism controlsbioRxiv : the preprint server for biology · 2025Article
- Amino acid competition shapes Acinetobacter baumannii gut carriage.Cell host & microbe · 2025Article
- Enhancement of anti-programmed cell death protein-1 immunotherapy in non-small cell lung cancer using arginine and citrulline supplementation.Journal of thoracic disease · 2025Article
- Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use.Nutrients · 2021Review
- Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice.The Journal of nutrition · 2020Article
- Activated whole-body arginine pathway in high-active mice.PloS one · 2020Article
- Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease.American journal of physiology. Renal physiology · 2018Article
- Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice.The Journal of nutrition · 2017Article
- Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.The Journal of nutrition · 2017Article
- Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.The Journal of infectious diseases · 2016Article
- Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice.The Journal of nutrition · 2015Article
- l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice.Frontiers in immunology · 2013Article
- De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs.American journal of physiology. Endocrinology and metabolism · 2012Article
- Arginine de novo and nitric oxide production in disease states.American journal of physiology. Endocrinology and metabolism · 2012Review
- Arginine and ornithine are the main precursors for citrulline synthesis in mice.The Journal of nutrition · 2012Article
- Is glutamine still an important precursor of citrulline?American journal of physiology. Endocrinology and metabolism · 2011Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The synthesis of citrulline from arginine in the small intestine depends on the provision of ornithine. To test the hypothesis that arginase II plays a central role in the supply of ornithine for citrulline synthesis, the contribution of dietary arginine, glutamine, and proline was determined by utilizing multitracer stable isotope protocols in arginase II knockout (AII(-/-)) and wild-type (WT) mice. The lack of arginase II resulted in a lower citrulline rate of appearance (121 vs. 137 μmol·kg(-1)·h(-1)) due to a reduced availability of ornithine; ornithine supplementation was able to restore the rate of citrulline production in AII(-/-) to levels comparable with WT mice. There were significant differences in the utilization of dietary citrulline precursors. The contribution of dietary arginine to the synthesis of citrulline was reduced from 45 to 10 μmol·kg(-1)·h(-1) due to the lack of arginase II. No enteral utilization of arginine was observed in AII(-/-) mice (WT = 25 μmol·kg(-1)·h(-1)), and the contribution of dietary arginine through plasma ornithine was reduced in the transgenic mice (20 vs. 13 μmol·kg(-1)·h(-1)). Dietary glutamine and proline utilization were greater in AII(-/-) than in WT mice (20 vs. 13 and 1.4 vs. 3.7 μmol·kg(-1)·h(-1), respectively). Most of the contribution of glutamine and proline was enteral rather than through plasma ornithine. The arginase isoform present in the small intestinal mucosa has the role of providing ornithine for citrulline synthesis. The lack of arginase II results in a greater contribution of plasma ornithine and dietary glutamine and proline to the synthesis of citrulline.
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