SynthesisCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysis.
Synthesis in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- F-box only protein 9 and its role in cancer.Molecular biology reports · 2022Review
- Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs.BMC cancer · 2019Article
- Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history.Familial cancer · 2019Article
- Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk.Oncotarget · 2018Article
- Effects of interactions between common genetic variants and smoking on colorectal cancer.BMC cancer · 2017Article
- Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.Oncotarget · 2017Article
- Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese.Oncotarget · 2016Article
- Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening.Future oncology (London, England) · 2016Review
- Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.Carcinogenesis · 2016Article
- Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.PloS one · 2016Article
- Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer.Gastroenterology · 2015Review
- Review
- A model to determine colorectal cancer risk using common genetic susceptibility loci.Gastroenterology · 2015Article
- Gene-diet interactions and their impact on colorectal cancer risk.Current nutrition reports · 2015Article
- Gene-environment interaction involving recently identified colorectal cancer susceptibility Loci.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer.PloS one · 2014Article
- Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival.Carcinogenesis · 2013Article
- Evaluation of allele-specific somatic changes of genome-wide association study susceptibility alleles in human colorectal cancers.PloS one · 2012Article
- NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.Cell cycle (Georgetown, Tex.) · 2011Article
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundA potential susceptibility locus for colorectal cancer on chromosome 9p24 (rs719725) was initially identified through a genome-wide association study, though replication attempts have been inconclusive.
methodsWe genotyped this locus and explored interactions with known risk factors as potential sources of heterogeneity, which may explain the previously inconsistent replication. We included Caucasians with colorectal adenoma or colorectal cancer and controls from 4 studies (total 3,891 cases, 4,490 controls): the Women's Health Initiative (WHI); the Diet, Activity and Lifestyle Study (DALS); a Minnesota population-based case-control study (MinnCCS); and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). We used logistic regression to evaluate the association and test for gene-environment interactions.
resultsSNP rs719725 was statistically significantly associated with risk of colorectal cancer in WHI (OR per A allele 1.19; 95% CI, 1.01-1.40; P(trend) = 0.04), marginally associated with adenoma risk in PLCO (OR per A allele 1.11; 95% CI, 0.99-1.25; P(trend) = 0.07), and not associated in DALS and MinnCCS. Evaluating for gene-environment interactions yielded no consistent results across the studies. A meta-analysis of 17 studies (including these 4) gave an OR per A allele of 1.07 (95% CI, 1.03-1.12; P(trend) = 0.001).
conclusionsOur results suggest the Aallele for SNP rs719725 at locus 9p24 is positively associated with a small increase in risk for colorectal tumors. Environmental risk factors for colorectal cancer do not appear to explain heterogeneity across studies. IMPACT: If this finding is supported by further replication and functional studies, it may highlight new pathways underlying colorectal neoplasia.
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