ArticleDevelopment (Cambridge, England)2010
Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Developmental exposure of antibiotics shortens life span and induces teratogenicity inToxicology reports · 2024Article
- Development of the ocellar visual system in Drosophila melanogaster.The FEBS journal · 2022Article
- Spalt and disco define the dorsal-ventral neuroepithelial compartments of the developing Drosophila medulla.Genetics · 2022Article
- Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient ineLife · 2022Article
- CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.Nature communications · 2022Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pinching and pushing: fold formation in the Drosophila dorsal epidermis.Biophysical journal · 2021Article
- The Pleiotropic Intricacies of Hedgehog Signaling: From Craniofacial Patterning to Carcinogenesis.FACE (Thousand Oaks, Calif.) · 2021Article
- Survival Following Traumatic Brain Injury inGenetics · 2020Article
- Article
- Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.Cell death & disease · 2018Review
- An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.eLife · 2016Article
- Article
- The Hedgehog Signalling Pathway in Cell Migration and Guidance: What We Have Learned from Drosophila melanogaster.Cancers · 2015Review
- Spatiotemporal regulation of GLI target genes in the mammalian limb bud.Developmental biology · 2015Article
- The intersection of the extrinsic hedgehog and WNT/wingless signals with the intrinsic Hox code underpins branching pattern and tube shape diversity in the drosophila airways.PLoS genetics · 2015Article
- Article
- Transcriptional regulation of graded Hedgehog signaling.Seminars in cell & developmental biology · 2014Review
- A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.Development (Cambridge, England) · 2014Article
- Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Paracrine Hedgehog (Hh) signaling regulates growth and patterning in many Drosophila organs. We mapped chromatin binding sites for Cubitus interruptus (Ci), the transcription factor that mediates outputs of Hh signal transduction, and we analyzed transcription profiles of control and mutant embryos to identify genes that are regulated by Hh. Putative targets that we identified included several Hh pathway components, mostly previously identified targets, and many targets that are novel. Every Hh target we analyzed that is not a pathway component appeared to be regulated by Hh in a tissue-specific manner; analysis of expression patterns of pathway components and target genes provided evidence of autocrine Hh signaling in the optic primordium of the embryo. We present evidence that tissue specificity of Hh targets depends on transcription factors that are Hh-independent, suggesting that `pre-patterns' of transcription factors partner with Ci to make Hh-dependent gene expression position specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.