ArticleBMJ (Clinical research ed.)2010
Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study.
Article in BMJ (Clinical research ed.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.
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Who cites it
82 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.Genome medicine · 2023Pooled it
- Combined Effect of Healthy Lifestyle Factors and Risks of Colorectal Adenoma, Colorectal Cancer, and Colorectal Cancer Mortality: Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Processed meat intake and incidence of colorectal cancer: a systematic review and meta-analysis of prospective observational studies.European journal of clinical nutrition · 2020Pooled it
- The impact of physical activity and an additional behavioural risk factor on cardiovascular disease, cancer and all-cause mortality: a systematic review.BMC public health · 2019Pooled it
- Trial
- Changing Behavioral Lifestyle Risk Factors Related to Cognitive Decline in Later Life Using a Self-Motivated eHealth Intervention in Dutch Adults.Journal of medical Internet research · 2016Trial
- Trial
- Impact of a comprehensive healthy lifestyle score on a broad spectrum of cardiometabolic and related diseases and its incremental value for risk prediction based on the UK biobank database.Journal of cardiothoracic surgery · 2026Article
- Analysis of Risk Factors and Assessment of miRNA-122 as a Novel Biomarker for Colon Cancer in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Cancer risk according to lifestyle risk score trajectories: a population-based cohort study.BJC reports · 2025Article
- Associations of an overall healthy lifestyle with the risk of metabolic dysfunction-associated fatty liver disease.BMC public health · 2024Article
- Dietary Minerals and Incident Cardiovascular Outcomes among Never-Smokers in a Danish Case-Cohort Study.International journal of environmental research and public health · 2024Article
- Article
- Alteration of Metabolic Syndrome Is Associated with the Decreased Risk of Colorectal Cancer.Journal of clinical medicine · 2023Article
- A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark.Clinical epidemiology · 2023Review
- Ketogenic Diet and Beta-Hydroxybutyrate in Colorectal Cancer.DNA and cell biology · 2022Article
- Pairwise association of key lifestyle factors and risk of colorectal cancer: a prospective pooled multicohort study.Cancer reports (Hoboken, N.J.) · 2022Article
- Adherence to a healthy lifestyle in relation to colorectal cancer incidence and all-cause mortality after endoscopic polypectomy: A prospective study in three U.S. cohorts.International journal of cancer · 2022Article
- The associations of healthy lifestyle index with breast cancer incidence and mortality in a population-based study.Breast cancer (Tokyo, Japan) · 2022Article
- Article
22 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the association between a simple lifestyle index based on the recommendations for five lifestyle factors and the incidence of colorectal cancer, and to estimate the proportion of colorectal cancer cases attributable to lack of adherence to the recommendations.
designProspective cohort study.
settingGeneral population of Copenhagen and Aarhus, Denmark.
participants55 487 men and women aged 50-64 years at baseline (1993-7), not previously diagnosed with cancer.
main outcome measureRisk of colorectal cancer in relation to points achieved in the lifestyle index (based on physical activity, waist circumference, smoking, alcohol intake, and diet (dietary fibre, energy percentage from fat, red and processed meat, and fruits and vegetables)) modelled through Cox regression.
resultsDuring a median follow-up of 9.9 years, 678 men and women had colorectal cancer diagnosed. After adjustment for potential confounders, each additional point achieved on the lifestyle index, corresponding to one additional recommendation that was met, was associated with a lower risk of colorectal cancer (incidence rate ratio 0.89 (95% confidence interval 0.82 to 0.96). In this population an estimated total of 13% (95% CI 4% to 22%) of the colorectal cancer cases were attributable to lack of adherence to merely one additional recommendation among all participants except the healthiest. If all participants had followed the five recommendations 23% (9% to 37%) of the colorectal cancer cases might have been prevented. Results were similar for colon and rectal cancer, but only statistically significant for colon cancer.
conclusionsAdherence to the recommendations for physical activity, waist circumference, smoking, alcohol intake, and diet may reduce colorectal cancer risk considerably, and in this population 23% of the cases might be attributable to lack of adherence to the five lifestyle recommendations. The simple structure of the lifestyle index facilitates its use in public health practice.
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