ArticleMolecular biology and evolution2011
Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 63 citations in OpenAlex.
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- Rapid Adaptation and Interspecific Introgression in the North American Crop Pest Helicoverpa zea.Molecular biology and evolution · 2024Article
- Blessing or curse: how the epigenetic resolution of host-transposable element conflicts shapes their evolutionary dynamics.Proceedings. Biological sciences · 2024Article
- Bacterial origins of human cell-autonomous innate immune mechanisms.Nature reviews. Immunology · 2022Review
- A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis.Nature communications · 2021Article
- Insecticidal RNA interference, thinking beyond long dsRNA.Pest management science · 2021Review
- Telomeric TART elements target the piRNA machinery in Drosophila.PLoS biology · 2020Article
- Inference of coevolutionary dynamics and parameters from host and parasite polymorphism data of repeated experiments.PLoS computational biology · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Arboviruses and the Challenge to Establish Systemic and Persistent Infections in Competent Mosquito Vectors: The Interaction With the RNAi Mechanism.Frontiers in physiology · 2019Review
- Coevolution of hytrosaviruses and host immune responses.BMC microbiology · 2018Review
- RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates.Genetics · 2018Article
- Review
- Environmental variation causes different (co) evolutionary routes to the same adaptive destination across parasite populations.Evolution letters · 2017Article
- Article
- Repeated Duplication of Argonaute2 Is Associated with Strong Selection and Testis Specialization in Drosophila.Genetics · 2016Article
- Variation and Evolution in the Glutamine-Rich Repeat Region of Drosophila Argonaute-2.G3 (Bethesda, Md.) · 2016Article
- The diversity of insect antiviral immunity: insights from viruses.Current opinion in microbiology · 2016Review
- Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.Molecular biology and evolution · 2016Article
- Addicted? Reduced host resistance in populations with defensive symbionts.Proceedings. Biological sciences · 2016Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Antagonistic host-parasite interactions can drive rapid adaptive evolution in genes of the immune system, and such arms races may be an important force shaping polymorphism in the genome. The RNA interference pathway gene Argonaute-2 (AGO2) is a key component of antiviral defense in Drosophila, and we have previously shown that genes in this pathway experience unusually high rates of adaptive substitution. Here we study patterns of genetic variation in a 100-kbp region around AGO2 in three different species of Drosophila. Our data suggest that recent independent selective sweeps in AGO2 have reduced genetic variation across a region of more than 50 kbp in Drosophila melanogaster, D. simulans, and D. yakuba, and we estimate that selection has fixed adaptive substitutions in this gene every 30-100 thousand years. The strongest signal of recent selection is evident in D. simulans, where we estimate that the most recent selective sweep involved an allele with a selective advantage of the order of 0.5-1% and occurred roughly 13-60 Kya. To evaluate the potential consequences of the recent substitutions on the structure and function of AGO2, we used fold-recognition and homology-based modeling to derive a structural model for the Drosophila protein, and this suggests that recent substitutions in D. simulans are overrepresented at the protein surface. In summary, our results show that selection by parasites can consistently target the same genes in multiple species, resulting in areas of the genome that have markedly reduced genetic diversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.