Trial reportPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2010
Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.
Trial report in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
- Trial
- Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode.The Journal of allergy and clinical immunology · 2015Trial
- Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Are we there yet? understanding interactions between respiratory viral infections, atopy, and the microbiome.Frontiers in allergy · 2026Review
- The usual suspects: Respiratory syncytial virus and rhinovirus drive asthma development and exacerbation.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025Review
- Childhood asthma diagnoses declined during the COVID-19 pandemic in the United States.Respiratory research · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Article
- Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.Biomedicines · 2022Review
- Rhinovirus Infections and Their Roles in Asthma: Etiology and Exacerbations.The journal of allergy and clinical immunology. In practice · 2022Review
- Atopic Neutrophils Prevent Postviral Airway Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Article
- Association of use of cleaning products with respiratory health in a Canadian birth cohort.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Role of viruses in asthma.Seminars in immunopathology · 2020Review
- Things We Do for No Reason: Systemic Corticosteroids for Wheezing in Preschool-Aged Children.Journal of hospital medicine · 2019Review
- Modulation of airway hyperresponsiveness by rhinovirus exposure.Respiratory research · 2018Review
- Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter.Allergy · 2018Article
- Role of viral infections in the development and exacerbation of asthma in children.The Journal of allergy and clinical immunology · 2017Review
- Rhinovirus-induced first wheezing episode predicts atopic but not nonatopic asthma at school age.The Journal of allergy and clinical immunology · 2017Article
- [The interactions between microorganisms and the small airways. A paediatric focus].Revue des maladies respiratoires · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on the link between atopy and viral wheeze are limited.
aimTo evaluate the association between IgE sensitization and viral infection in wheezing children.
methodsThis is an observational study in hospitalized wheezing children (n = 247; median age 1.6 ; interquartile range 1.1, 2.9). Eighteen respiratory viral infections were studied using all available methods. A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy-related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology.
resultsAtopy was closely associated with sole rhinovirus etiology (n = 58) but not with sole respiratory syncytial virus, sole enterovirus, sole human bocavirus, sole other virus, mixed viral, or virus negative etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13).
conclusionsAccording to our data, allergic sensitization is positively linked to rhinovirus-, but not other virus-, associated wheezing and calls attention for studies to test rhinovirus-associated wheezing as a part of asthma risk indices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.