ArticleJournal of anatomy2011
Methodological considerations for analyzing trabecular architecture: an example from the primate hand.
Article in Journal of anatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 79 citations in OpenAlex.
- Whole-Epiphysis Trabecular Bone in Tamarin Limbs Suggests Effects of Leaping Distance Alongside Non-Biomechanical Factors.American journal of biological anthropology · 2026Article
- Trabecular Architecture of the Proximal Tibia in Extant Hominids.American journal of biological anthropology · 2025Article
- How compactness affects long bone resistance to compression-An investigation into the rhinoceros humerus.Journal of anatomy · 2025Article
- Trabecular Bone Ontogeny of the Human Distal Tibia.American journal of biological anthropology · 2025Article
- A macroevolutionary common-garden experiment reveals differentially evolvable bone organization levels in slow arboreal mammals.Communications biology · 2023Article
- From Fairies to Giants: Untangling the Effect of Body Size, Phylogeny, and Ecology on Vertebral Bone Microstructure of Xenarthran Mammals.Integrative organismal biology (Oxford, England) · 2023Article
- A computational framework for canonical holistic morphometric analysis of trabecular bone.Scientific reports · 2022Article
- A Shrewd Inspection of Vertebral Regionalization in Large Shrews (Soricidae: Crocidurinae).Integrative organismal biology (Oxford, England) · 2022Article
- Novel strategies for the characterization of cancellous bone morphology: Virtual isolation and analysis.American journal of physical anthropology · 2021Article
- Differing effects of size and lifestyle on bone structure in mammals.BMC biology · 2021Article
- Deciphering an extreme morphology: bone microarchitecture of the hero shrew backbone (Soricidae:Proceedings. Biological sciences · 2020Article
- Ontogenetic changes to bone microstructure in an archaeologically derived sample of human ribs.Journal of anatomy · 2020Article
- Trabecular bone architecture in the stylopod epiphyses of mustelids (Mammalia, Carnivora).Royal Society open science · 2019Article
- Metacarpal trabecular bone varies with distinct hand-positions used in hominid locomotion.Journal of anatomy · 2019Article
- Trabecular architecture of the great ape and human femoral head.Journal of anatomy · 2019Article
- Systemic patterns of trabecular bone across the human and chimpanzee skeleton.Journal of anatomy · 2018Article
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- Trabecular architecture in the sciuromorph femoral head: allometry and functional adaptation.Zoological letters · 2018Article
- A robust methodology for the quantitative assessment of the rat jawbone microstructure.International journal of oral science · 2017Article
- Laterality and grip strength influence hand bone micro-architecture in modern humans, an HRpQCT study.Journal of anatomy · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro-computed tomographic analyses of trabecular bone architecture have been used to clarify the link between positional behavior and skeletal anatomy in primates. However, there are methodological decisions associated with quantifying and comparing trabecular anatomy across taxa that vary greatly in body size and morphology that can affect characterizations of trabecular architecture, such as choice of the volume of interest (VOI) size and location. The potential effects of these decisions may be amplified in small, irregular-shaped bones of the hands and feet that have more complex external morphology and more heterogeneous trabecular structure compared to, for example, the spherical epiphysis of the femoral head. In this study we investigate the effects of changes in VOI size and location on standard trabecular parameters in two bones of the hand, the capitate and third metacarpal, in a diverse sample of nonhuman primates that vary greatly in morphology, body mass and positional behavior. Results demonstrate that changes in VOI location and, to a lesser extent, changes in VOI size had a dramatic affect on many trabecular parameters, especially trabecular connectivity and structure (rods vs. plates), degree of anisotropy, and the primary orientation of the trabeculae. Although previous research has shown that some trabecular parameters are susceptible to slight variations in methodology (e.g. VOI location, scan resolution), this study provides a quantification of these effects in hand bones of a diverse sample of primates. An a priori understanding of the inherent biases created by the choice of VOI size and particularly location is critical to robust trabecular analysis and functional interpretation, especially in small bones with complex arthroses.
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